Stress, superoxide, and signal transduction

Pascal J. Goldschmidt-Clermont, Leni Moldovan

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

A variety of stressful events can trigger the production of free radicals by exposed cells. For years, the effect of such highly reactive radicals was expected to be damaging to cells, altering their biology irreversibly. However, many recent reports have shown that reactive oxygen species can have additional functions, and contribute to important signaling pathways to regulate key biological responses, including cell migration, mitosis, and apoptosis. With this review, we address the role of the small GTP binding protein, Rac, as a regulatory protein that controls superoxide production, and the effect of superoxide and derived oxidants in cell signaling.

Original languageEnglish (US)
Pages (from-to)255-260
Number of pages6
JournalGene expression
Volume7
Issue number4-6
StatePublished - 1999

Keywords

  • Actin
  • Rac
  • Reactive oxygen species
  • Review
  • Signal transduction
  • Small GTP binding proteins
  • Stress
  • Superoxide

ASJC Scopus subject areas

  • Genetics

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