Stress reactivity in social anxiety disorder with and without comorbid depression.

K. Lira Yoon, Jutta Joormann

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Previous research on neuroendocrine responding to a psychological stressor in individuals with Social Anxiety Disorder (SAD) has provided inconsistent results. A recent meta-analysis concluded that Major Depressive Disorder (MDD), which is frequently comorbid with SAD, is associated with blunted stress reactivity. It is, thus, possible that comorbidity status contributes to the inconsistent findings in the SAD literature. In this study, salivary cortisol responses to a psychological stressor were examined in three groups: healthy controls (CTL), SAD, and SAD with comorbid MDD (COM). The SAD group differed from the other two groups in their cortisol stress reactivity. It is important to note that analyses combining participants with SAD with and without comorbid MDD obscured findings of cortisol reactivity. In addition, the differences in cortisol reactivity cannot be accounted for by participants' affective responses to the stressor. The current findings indicate that individuals with SAD exhibit distinct stress-related cortisol responses depending on their comorbidity statuses. PsycINFO Database Record (c) 2012 APA, all rights reserved.

Original languageEnglish (US)
Pages (from-to)250-255
Number of pages6
JournalJournal of abnormal psychology
Issue number1
StatePublished - Feb 1 2012

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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