Stress management skills, cortisol awakening response, and post-exertional malaise in Chronic Fatigue Syndrome

Daniel L. Hall, Emily G. Lattie, Michael H Antoni, Mary Ann Fletcher, Sara J Czaja, Dolores Perdomo, Nancy G. Klimas

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Chronic Fatigue Syndrome (CFS) is characterized in part by debilitating fatigue typically exacerbated by cognitive and/or physical exertion, referred to as post-exertional malaise (PEM). In a variety of populations, the cortisol awakening response (CAR) has stood out as a marker of endocrine dysregulation relevant to the experience of fatigue, and may therefore be particularly relevant in CFS. This is the first study to examine PEM and the CAR in a sample of individuals with CFS. The CAR has also been established as a stress-sensitive measure of HPA axis functioning. It follows that better management of stress could modulate the CAR, and in turn PEM. In this cross-sectional study, we hypothesized that greater Perceived Stress Management Skills (PSMS) would relate to lower reports of PEM, via the impact of PSMS on the CAR. A total of 117 adults (72% female) with a CFS diagnosis completed self-report measures of PSMS and PEM symptomatology and a two-day protocol of saliva collection. Cortisol values from awakening and 30. min post-awakening were used to compute the CAR. Regression analyses revealed that greater PSMS related to greater CAR and greater CAR related to less PEM severity. Bootstrapped analyses revealed an indirect effect of PSMS on PEM via the CAR, such that greater PSMS related to less PEM, via a greater CAR. Future research should examine these trends longitudinally and whether interventions directed at improving stress management skills are accompanied by improved cortisol regulation and less PEM in individuals with CFS.

Original languageEnglish
Pages (from-to)26-31
Number of pages6
JournalPsychoneuroendocrinology
Volume49
Issue number1
DOIs
StatePublished - 2014

Fingerprint

Chronic Fatigue Syndrome
Hydrocortisone
Fatigue
Physical Exertion
Saliva
Self Report
Cross-Sectional Studies

Keywords

  • Chronic Fatigue Syndrome
  • Cortisol
  • HPA axis
  • Stress management

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems

Cite this

Stress management skills, cortisol awakening response, and post-exertional malaise in Chronic Fatigue Syndrome. / Hall, Daniel L.; Lattie, Emily G.; Antoni, Michael H; Fletcher, Mary Ann; Czaja, Sara J; Perdomo, Dolores; Klimas, Nancy G.

In: Psychoneuroendocrinology, Vol. 49, No. 1, 2014, p. 26-31.

Research output: Contribution to journalArticle

Hall, Daniel L. ; Lattie, Emily G. ; Antoni, Michael H ; Fletcher, Mary Ann ; Czaja, Sara J ; Perdomo, Dolores ; Klimas, Nancy G. / Stress management skills, cortisol awakening response, and post-exertional malaise in Chronic Fatigue Syndrome. In: Psychoneuroendocrinology. 2014 ; Vol. 49, No. 1. pp. 26-31.
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