Abstract
We present a psychoneuroimmunologic (PNI) model for Human Immunodeficiency Virus (HIV) infection, describe a 10-week group-based cognitive behavioral stress management (CBSM) intervention and summarize research demonstrating the effects of this intervention on mood, neuroendocrine (Hypothalamic Pituitary Adrenal [HPA], Hypothalamic Pituitary Gonadal [HPG] and Sympathetic Nervous System [SNS] hormones) and immune system status (lymphocyte subsets, antiviral immune function) in HIV-infected persons. This work demonstrates that changes in relaxation skills, cognitive coping strategies and social support may mediate the mood effects of CBSM, and that these mood changes may mediate adrenal hormone regulation indicated by reductions in 24-h urinary cortisol (with reduced depressed mood) and norepinephrine (with reduced anxiety) and increases in serum DHEA-S and testosterone levels (with reduced depressed mood). Results also suggest that CBSM-related changes in production of these hormones may explain, in part, the effects of this intervention on short-term changes in IgG antibody titers to herpesviruses (with increased DHEA-S-to-cortisol ratio), and longer-term changes in lymphocyte subpopulations such as CD8 suppressor/cytotoxic cells (with reductions in urinary noradrenaline output) and transitional naïve CD4 cells (with reductions in urinary cortisol output). Thus a multi-modal CBSM intervention is associated with alterations in mood, neuroendocrine functioning and immunologic status that may have health implications for HIV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 173-188 |
| Number of pages | 16 |
| Journal | Stress |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2003 |
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Keywords
- AIDS
- Cognitive behavioral stress management
- Hypothalamic-pituitary-adrenal axis
- Immune function
- Psychoneuroimmunology
- Relaxation
ASJC Scopus subject areas
- Neuroscience(all)
- Physiology
Cite this
Stress management effects on psychological, endocrinological, and immune functioning in men with HIV infection : Empirical support for a psychoneuroimmunological model. / Antoni, Michael H.
In: Stress, Vol. 6, No. 3, 01.09.2003, p. 173-188.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stress management effects on psychological, endocrinological, and immune functioning in men with HIV infection
T2 - Empirical support for a psychoneuroimmunological model
AU - Antoni, Michael H
PY - 2003/9/1
Y1 - 2003/9/1
N2 - We present a psychoneuroimmunologic (PNI) model for Human Immunodeficiency Virus (HIV) infection, describe a 10-week group-based cognitive behavioral stress management (CBSM) intervention and summarize research demonstrating the effects of this intervention on mood, neuroendocrine (Hypothalamic Pituitary Adrenal [HPA], Hypothalamic Pituitary Gonadal [HPG] and Sympathetic Nervous System [SNS] hormones) and immune system status (lymphocyte subsets, antiviral immune function) in HIV-infected persons. This work demonstrates that changes in relaxation skills, cognitive coping strategies and social support may mediate the mood effects of CBSM, and that these mood changes may mediate adrenal hormone regulation indicated by reductions in 24-h urinary cortisol (with reduced depressed mood) and norepinephrine (with reduced anxiety) and increases in serum DHEA-S and testosterone levels (with reduced depressed mood). Results also suggest that CBSM-related changes in production of these hormones may explain, in part, the effects of this intervention on short-term changes in IgG antibody titers to herpesviruses (with increased DHEA-S-to-cortisol ratio), and longer-term changes in lymphocyte subpopulations such as CD8 suppressor/cytotoxic cells (with reductions in urinary noradrenaline output) and transitional naïve CD4 cells (with reductions in urinary cortisol output). Thus a multi-modal CBSM intervention is associated with alterations in mood, neuroendocrine functioning and immunologic status that may have health implications for HIV infection.
AB - We present a psychoneuroimmunologic (PNI) model for Human Immunodeficiency Virus (HIV) infection, describe a 10-week group-based cognitive behavioral stress management (CBSM) intervention and summarize research demonstrating the effects of this intervention on mood, neuroendocrine (Hypothalamic Pituitary Adrenal [HPA], Hypothalamic Pituitary Gonadal [HPG] and Sympathetic Nervous System [SNS] hormones) and immune system status (lymphocyte subsets, antiviral immune function) in HIV-infected persons. This work demonstrates that changes in relaxation skills, cognitive coping strategies and social support may mediate the mood effects of CBSM, and that these mood changes may mediate adrenal hormone regulation indicated by reductions in 24-h urinary cortisol (with reduced depressed mood) and norepinephrine (with reduced anxiety) and increases in serum DHEA-S and testosterone levels (with reduced depressed mood). Results also suggest that CBSM-related changes in production of these hormones may explain, in part, the effects of this intervention on short-term changes in IgG antibody titers to herpesviruses (with increased DHEA-S-to-cortisol ratio), and longer-term changes in lymphocyte subpopulations such as CD8 suppressor/cytotoxic cells (with reductions in urinary noradrenaline output) and transitional naïve CD4 cells (with reductions in urinary cortisol output). Thus a multi-modal CBSM intervention is associated with alterations in mood, neuroendocrine functioning and immunologic status that may have health implications for HIV infection.
KW - AIDS
KW - Cognitive behavioral stress management
KW - Hypothalamic-pituitary-adrenal axis
KW - Immune function
KW - Psychoneuroimmunology
KW - Relaxation
UR - http://www.scopus.com/inward/record.url?scp=0141867638&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141867638&partnerID=8YFLogxK
U2 - 10.1080/1025389031000156727
DO - 10.1080/1025389031000156727
M3 - Article
C2 - 13129811
AN - SCOPUS:0141867638
VL - 6
SP - 173
EP - 188
JO - Stress
JF - Stress
SN - 1025-3890
IS - 3
ER -