Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways

Petra Clara Arck, Bori Handjiski, Eva Milena J. Peters, Anita S. Peter, Evelin Hagen, Axel Fischer, Burghard F. Klapp, Ralf Paus

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

It has been much disputed whether or not stress can cause hair loss (telogen effluvium) in a clinically relevant manner. Despite the paramount psychosocial importance of hair in human society, this central, yet enigmatic and controversial problem of clinically applied stress research has not been systematically studied in appropriate animal models. We now show that psychoemotional stress indeed alters actual hair follicle (HF) cycling in vivo, ie, prematurely terminates the normal duration of active hair growth (anagen) in mice. Further, inflammatory events deleterious to the HF are present in the HF environment of stressed mice (perifollicular macrophage duster, excessive mast cell activation). This provides the first solid pathophysiological mechanism for how stress may actually cause telogen effluvium, ie, by hair cycle manipulation and neuroimmunological events that combine to terminate anagen. Furthermore, we show that most of these hair growth-inhibitory effects of stress can be reproduced by the proteotypic stressrelated neuropeptide substance P in nonstressed mice, and can be counteracted effectively by co-administration of a specific substance P receptor antagonist in stressed mice. This offers the first convincing rationale how stress-induced hair loss in men may be pharmacologically managed effectively.

Original languageEnglish (US)
Pages (from-to)803-814
Number of pages12
JournalAmerican Journal of Pathology
Volume162
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

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Substance P
Neuropeptides
Hair
Hair Follicle
Alopecia
Growth
Neurokinin-1 Receptor Antagonists
Mast Cells
Animal Models
Macrophages
Research

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways. / Arck, Petra Clara; Handjiski, Bori; Peters, Eva Milena J.; Peter, Anita S.; Hagen, Evelin; Fischer, Axel; Klapp, Burghard F.; Paus, Ralf.

In: American Journal of Pathology, Vol. 162, No. 3, 01.03.2003, p. 803-814.

Research output: Contribution to journalArticle

Arck, Petra Clara ; Handjiski, Bori ; Peters, Eva Milena J. ; Peter, Anita S. ; Hagen, Evelin ; Fischer, Axel ; Klapp, Burghard F. ; Paus, Ralf. / Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways. In: American Journal of Pathology. 2003 ; Vol. 162, No. 3. pp. 803-814.
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