Stress-induced neurogenic inflammation in murine skin skews dendritic cells towards maturation and migration

Key role of intercellular adhesion molecule-1/leukocyte function-associated antigen interactions

Ricarda Alcira Joachim, Bori Handjiski, Sandra Maria Blois, Evelin Hagen, Ralf Paus, Petra Clara Arck

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The skin continuously serves as a biosensor of multiple exogenous stressors and integrates the resulting responses with an individual's central and peripheral endogenous response systems to perceived stress; it also acts to protect against external challenges such as wounding and infection. We have previously shown in mice that stress induces nerve growth factor-and substance P-dependent neurogenic inflammation, which includes the prominent clustering of MHC class II+ cells. Because the contribution of dendritic cells (DCs) in response to stress is not well understood, we examined the role of DCs in neurogenic inflammation in murine skin using a well-established murine stress model. We show that sound stress increases the number of intradermal langerin+ and CD11c+ DCs and induces DC maturation, as indicated by the up-regulated expression of CD11c, MHC class II, and intercellular adhesion molecule-1 (ICAM-1). Blocking of ICAM-1/leukocyte function-associated antigen-1 interactions significantly abrogated the stress-induced numeric increase, maturation, and migration of dermal DCs in vivo and also reduced stress-induced keratinocyte apoptosis and endothelial cell expression of ICAM-1. In conclusion, stress exposure causes a state of immune alertness in the skin. Such adaptation processes may ensure protection from possible infections on wounding by stressors, such as attack by predators. However, present-day stressors have changed and such adaptations appear redundant and may overrun skin homeostasis by inducing immune dermatoses.

Original languageEnglish (US)
Pages (from-to)1379-1388
Number of pages10
JournalAmerican Journal of Pathology
Volume173
Issue number5
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

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Neurogenic Inflammation
Langerhans Cells
Intercellular Adhesion Molecule-1
Dendritic Cells
Leukocytes
Antigens
Skin
Lymphocyte Function-Associated Antigen-1
Biosensing Techniques
Nerve Growth Factor
Substance P
Infection
Keratinocytes
Skin Diseases
Cluster Analysis
Homeostasis
Endothelial Cells
Apoptosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Stress-induced neurogenic inflammation in murine skin skews dendritic cells towards maturation and migration : Key role of intercellular adhesion molecule-1/leukocyte function-associated antigen interactions. / Joachim, Ricarda Alcira; Handjiski, Bori; Blois, Sandra Maria; Hagen, Evelin; Paus, Ralf; Arck, Petra Clara.

In: American Journal of Pathology, Vol. 173, No. 5, 01.01.2008, p. 1379-1388.

Research output: Contribution to journalArticle

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