Effective immunoprotection requires rapid recruitment of leukocytes into sites of surgery, wounding, infection, or vaccination. Immune cells circulate continuously on surveillance pathways that take them from the blood, through various organs, and back into the blood. This circulation is essential for the maintenance of an effective immune defense network (Sprent and Tough, 1994).The numbers and proportions of leukocytes in the blood provide an important representation of the state of distribution of leukocytes in the body and of the state of activation of the immune system. A stress-induced change in leukocyte distribution within different body compartments is perhaps one of the most underappreciated effects of stress and stress hormones on the immune system.
|Original language||English (US)|
|Title of host publication||Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity|
|Number of pages||19|
|ISBN (Print)||0387314113, 9780387314112|
|State||Published - Dec 1 2006|
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