Stress-induced changes in immune cell distribution and trafficking: Implications for immunoprotection versus immunopathology

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

Effective immunoprotection requires rapid recruitment of leukocytes into sites of surgery, wounding, infection, or vaccination. Immune cells circulate continuously on surveillance pathways that take them from the blood, through various organs, and back into the blood. This circulation is essential for the maintenance of an effective immune defense network (Sprent and Tough, 1994).The numbers and proportions of leukocytes in the blood provide an important representation of the state of distribution of leukocytes in the body and of the state of activation of the immune system. A stress-induced change in leukocyte distribution within different body compartments is perhaps one of the most underappreciated effects of stress and stress hormones on the immune system.

Original languageEnglish (US)
Title of host publicationNeural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity
PublisherSpringer US
Pages7-25
Number of pages19
ISBN (Print)0387314113, 9780387314112
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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