Stress increases peripheral axon growth and regeneration through glucocorticoid receptor-dependent transcriptional programs

Jessica K. Lerch, Jessica K. Alexander, Kathryn M. Madalena, Dario Motti, Tam Quach, Akhil Dhamija, Alicia Zha, John C. Gensel, Jeanette Webster Marketon, Vance Lemmon, John Bixby, Phillip G. Popovich

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Stress and glucocorticoid (GC) release are common behavioral and hormonal responses to injury or disease. In the brain, stress/GCs can alter neuron structure and function leading to cognitive impairment. Stress and GCs also exacerbate pain, but whether a corresponding change occurs in structural plasticity of sensory neurons is unknown. Here, we show that in female mice (Mus musculus) basal GC receptor (Nr3c1, also known as GR) expression in dorsal root ganglion (DRG) sensory neurons is 15-fold higher than in neurons in canonical stress-responsive brain regions (M. musculus). In response to stress or GCs, adult DRG neurite growth increases through mechanisms involving GR-dependent gene transcription. In vivo, prior exposure to an acute systemic stress increases peripheral nerve regeneration. These data have broad clinical implications and highlight the importance of stress and GCs as novel behavioral and circulating modifiers of neuronal plasticity.

Original languageEnglish (US)
Article numbere0246-17.2017
JournaleNeuro
Volume4
Issue number4
DOIs
StatePublished - Jul 1 2017

Fingerprint

Glucocorticoid Receptors
Axons
Regeneration
Spinal Ganglia
Sensory Receptor Cells
Growth
Neurons
Nerve Regeneration
Neuronal Plasticity
Brain
Neurites
Peripheral Nerves
Glucocorticoids
Pain
Wounds and Injuries
Genes

Keywords

  • Dorsal root ganglia
  • Glucocorticoid receptor
  • Plasticity
  • Stress

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lerch, J. K., Alexander, J. K., Madalena, K. M., Motti, D., Quach, T., Dhamija, A., ... Popovich, P. G. (2017). Stress increases peripheral axon growth and regeneration through glucocorticoid receptor-dependent transcriptional programs. eNeuro, 4(4), [e0246-17.2017]. https://doi.org/10.1523/ENEURO.0246-17.2017

Stress increases peripheral axon growth and regeneration through glucocorticoid receptor-dependent transcriptional programs. / Lerch, Jessica K.; Alexander, Jessica K.; Madalena, Kathryn M.; Motti, Dario; Quach, Tam; Dhamija, Akhil; Zha, Alicia; Gensel, John C.; Marketon, Jeanette Webster; Lemmon, Vance; Bixby, John; Popovich, Phillip G.

In: eNeuro, Vol. 4, No. 4, e0246-17.2017, 01.07.2017.

Research output: Contribution to journalArticle

Lerch, JK, Alexander, JK, Madalena, KM, Motti, D, Quach, T, Dhamija, A, Zha, A, Gensel, JC, Marketon, JW, Lemmon, V, Bixby, J & Popovich, PG 2017, 'Stress increases peripheral axon growth and regeneration through glucocorticoid receptor-dependent transcriptional programs', eNeuro, vol. 4, no. 4, e0246-17.2017. https://doi.org/10.1523/ENEURO.0246-17.2017
Lerch, Jessica K. ; Alexander, Jessica K. ; Madalena, Kathryn M. ; Motti, Dario ; Quach, Tam ; Dhamija, Akhil ; Zha, Alicia ; Gensel, John C. ; Marketon, Jeanette Webster ; Lemmon, Vance ; Bixby, John ; Popovich, Phillip G. / Stress increases peripheral axon growth and regeneration through glucocorticoid receptor-dependent transcriptional programs. In: eNeuro. 2017 ; Vol. 4, No. 4.
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