Abstract
Depression and coronary heart disease (CHD) are leading contributors to disease burden in women. CHD and depression are comorbid; whether they have common etiology or depression causes CHD is unclear. The underlying pathology of CHD, coronary artery atherosclerosis (CAA), is present decades before CHD, and the temporal relationship between depression and CAA is unclear. The evidence of involvement of depression in early CAA in cynomolgus monkeys, an established model of CAA and depression, is summarized. Like people, monkeys may respond to the stress of low social status with depressive behavior accompanied by perturbations in hypothalamic-pituitary-adrenal (HPA), autonomic nervous system, lipid metabolism, ovarian, and neural serotonergic system function, all of which are associated with exacerbated CAA. The primate data are consistent with the hypothesis that depression may cause CAA, and also with the hypothesis that CAA and depression may be the result of social stress. More study is needed to discriminate between these two possibilities. The primate data paint a compelling picture of depression as a whole-body disease.
| Original language | English |
|---|---|
| Pages (from-to) | 133-144 |
| Number of pages | 12 |
| Journal | Neuroscience and Biobehavioral Reviews |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2009 |
| Externally published | Yes |
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Keywords
- Cholesterol
- Coronary heart disease
- Depression
- Heart rate
- Inflammation
- Neural serotonergic function
- Ovarian function
- Platelet reactivity
ASJC Scopus subject areas
- Behavioral Neuroscience
- Cognitive Neuroscience
- Neuropsychology and Physiological Psychology
Cite this
Stress, depression, and coronary artery disease : Modeling comorbidity in female primates. / Shively, Carol A.; Musselman, Dominique; Willard, Stephanie L.
In: Neuroscience and Biobehavioral Reviews, Vol. 33, No. 2, 01.02.2009, p. 133-144.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stress, depression, and coronary artery disease
T2 - Modeling comorbidity in female primates
AU - Shively, Carol A.
AU - Musselman, Dominique
AU - Willard, Stephanie L.
PY - 2009/2/1
Y1 - 2009/2/1
N2 - Depression and coronary heart disease (CHD) are leading contributors to disease burden in women. CHD and depression are comorbid; whether they have common etiology or depression causes CHD is unclear. The underlying pathology of CHD, coronary artery atherosclerosis (CAA), is present decades before CHD, and the temporal relationship between depression and CAA is unclear. The evidence of involvement of depression in early CAA in cynomolgus monkeys, an established model of CAA and depression, is summarized. Like people, monkeys may respond to the stress of low social status with depressive behavior accompanied by perturbations in hypothalamic-pituitary-adrenal (HPA), autonomic nervous system, lipid metabolism, ovarian, and neural serotonergic system function, all of which are associated with exacerbated CAA. The primate data are consistent with the hypothesis that depression may cause CAA, and also with the hypothesis that CAA and depression may be the result of social stress. More study is needed to discriminate between these two possibilities. The primate data paint a compelling picture of depression as a whole-body disease.
AB - Depression and coronary heart disease (CHD) are leading contributors to disease burden in women. CHD and depression are comorbid; whether they have common etiology or depression causes CHD is unclear. The underlying pathology of CHD, coronary artery atherosclerosis (CAA), is present decades before CHD, and the temporal relationship between depression and CAA is unclear. The evidence of involvement of depression in early CAA in cynomolgus monkeys, an established model of CAA and depression, is summarized. Like people, monkeys may respond to the stress of low social status with depressive behavior accompanied by perturbations in hypothalamic-pituitary-adrenal (HPA), autonomic nervous system, lipid metabolism, ovarian, and neural serotonergic system function, all of which are associated with exacerbated CAA. The primate data are consistent with the hypothesis that depression may cause CAA, and also with the hypothesis that CAA and depression may be the result of social stress. More study is needed to discriminate between these two possibilities. The primate data paint a compelling picture of depression as a whole-body disease.
KW - Cholesterol
KW - Coronary heart disease
KW - Depression
KW - Heart rate
KW - Inflammation
KW - Neural serotonergic function
KW - Ovarian function
KW - Platelet reactivity
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U2 - 10.1016/j.neubiorev.2008.06.006
DO - 10.1016/j.neubiorev.2008.06.006
M3 - Article
C2 - 18619999
AN - SCOPUS:56949102073
VL - 33
SP - 133
EP - 144
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
IS - 2
ER -