Stress as a predictor of symptomatic genetical herpes virus recurrence in women with human immunodeficiency virus

Deidre Byrnes Pereira, Michael H Antoni, Aimee Danielson, Trudi Simon, JoNell E Potter, Charles S Carver, Ron E F Durán, Gail Ironson, Nancy Klimas, Mary Ann Fletcher, Mary Jo O'Sullivan

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective: Genital herpes (Herpes Simplex Virus Type 2, HSV-2) is a significant public health problem for HIV+ women, who have high rates of HSV-2 seropositivity and elevated risk for HSV-2 associated morbidity and mortality. Life stress has been identified as a co-factor in genital herpes recurrence. However, no research has evaluated the relationship between stress and genital herpes recurrences in HIV+ women. The purpose of this study was to determine whether stress was associated with symptomatic genital herpes recurrences in women seropositive for HIV and HSV-2. Methods: Thirty-four HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw and gynecologic examination to assess gynecologic symptoms (including genital herpes) at study entry. Life stress was measured using a 10-item modified version of the Life Experiences Survey (LES). Genital herpes recurrence over 1-year follow-up was abstracted using medical chart review. Results: Using hierarchical linear regression analysis, life stress at study entry was significantly associated with number of genital herpes recurrences during 1-year follow-up (β = .38, P =.03) after controlling for HIV disease variables and relevant behavioral factors. Recent life stress, in particular, was highly predictive of genital herpes recurrence during follow-up (β = .57, P= .002). The relationship between life stress and genital herpes recurrence persisted after controlling for HSV-2 viral reactivation (i.e., HSV-2 IgG titers) at study entry. Conclusion: These findings suggest that stress may be a significant predictor of genital herpes recurrence in women with HIV and HSV-2. Stress management interventions may buffer HSV-related morbidity and mortality in women with HIV.

Original languageEnglish
Pages (from-to)237-244
Number of pages8
JournalJournal of Psychosomatic Research
Volume54
Issue number3
DOIs
StatePublished - Mar 1 2003

Fingerprint

Herpes Genitalis
Human Herpesvirus 2
HIV
Viruses
Recurrence
Psychological Stress
Morbidity
Mortality
Life Change Events
African Americans
Linear Models
Buffers
Public Health
Immunoglobulin G
Regression Analysis
Interviews

Keywords

  • Genital herpes
  • HIV
  • Stress
  • Women

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Stress as a predictor of symptomatic genetical herpes virus recurrence in women with human immunodeficiency virus. / Pereira, Deidre Byrnes; Antoni, Michael H; Danielson, Aimee; Simon, Trudi; Potter, JoNell E; Carver, Charles S; Durán, Ron E F; Ironson, Gail; Klimas, Nancy; Fletcher, Mary Ann; O'Sullivan, Mary Jo.

In: Journal of Psychosomatic Research, Vol. 54, No. 3, 01.03.2003, p. 237-244.

Research output: Contribution to journalArticle

Pereira, Deidre Byrnes ; Antoni, Michael H ; Danielson, Aimee ; Simon, Trudi ; Potter, JoNell E ; Carver, Charles S ; Durán, Ron E F ; Ironson, Gail ; Klimas, Nancy ; Fletcher, Mary Ann ; O'Sullivan, Mary Jo. / Stress as a predictor of symptomatic genetical herpes virus recurrence in women with human immunodeficiency virus. In: Journal of Psychosomatic Research. 2003 ; Vol. 54, No. 3. pp. 237-244.
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AU - Potter, JoNell E

AU - Carver, Charles S

AU - Durán, Ron E F

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AB - Objective: Genital herpes (Herpes Simplex Virus Type 2, HSV-2) is a significant public health problem for HIV+ women, who have high rates of HSV-2 seropositivity and elevated risk for HSV-2 associated morbidity and mortality. Life stress has been identified as a co-factor in genital herpes recurrence. However, no research has evaluated the relationship between stress and genital herpes recurrences in HIV+ women. The purpose of this study was to determine whether stress was associated with symptomatic genital herpes recurrences in women seropositive for HIV and HSV-2. Methods: Thirty-four HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw and gynecologic examination to assess gynecologic symptoms (including genital herpes) at study entry. Life stress was measured using a 10-item modified version of the Life Experiences Survey (LES). Genital herpes recurrence over 1-year follow-up was abstracted using medical chart review. Results: Using hierarchical linear regression analysis, life stress at study entry was significantly associated with number of genital herpes recurrences during 1-year follow-up (β = .38, P =.03) after controlling for HIV disease variables and relevant behavioral factors. Recent life stress, in particular, was highly predictive of genital herpes recurrence during follow-up (β = .57, P= .002). The relationship between life stress and genital herpes recurrence persisted after controlling for HSV-2 viral reactivation (i.e., HSV-2 IgG titers) at study entry. Conclusion: These findings suggest that stress may be a significant predictor of genital herpes recurrence in women with HIV and HSV-2. Stress management interventions may buffer HSV-related morbidity and mortality in women with HIV.

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