Abstract
Objective: Genital herpes (Herpes Simplex Virus Type 2, HSV-2) is a significant public health problem for HIV+ women, who have high rates of HSV-2 seropositivity and elevated risk for HSV-2 associated morbidity and mortality. Life stress has been identified as a co-factor in genital herpes recurrence. However, no research has evaluated the relationship between stress and genital herpes recurrences in HIV+ women. The purpose of this study was to determine whether stress was associated with symptomatic genital herpes recurrences in women seropositive for HIV and HSV-2. Methods: Thirty-four HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw and gynecologic examination to assess gynecologic symptoms (including genital herpes) at study entry. Life stress was measured using a 10-item modified version of the Life Experiences Survey (LES). Genital herpes recurrence over 1-year follow-up was abstracted using medical chart review. Results: Using hierarchical linear regression analysis, life stress at study entry was significantly associated with number of genital herpes recurrences during 1-year follow-up (β = .38, P =.03) after controlling for HIV disease variables and relevant behavioral factors. Recent life stress, in particular, was highly predictive of genital herpes recurrence during follow-up (β = .57, P= .002). The relationship between life stress and genital herpes recurrence persisted after controlling for HSV-2 viral reactivation (i.e., HSV-2 IgG titers) at study entry. Conclusion: These findings suggest that stress may be a significant predictor of genital herpes recurrence in women with HIV and HSV-2. Stress management interventions may buffer HSV-related morbidity and mortality in women with HIV.
| Original language | English |
|---|---|
| Pages (from-to) | 237-244 |
| Number of pages | 8 |
| Journal | Journal of Psychosomatic Research |
| Volume | 54 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2003 |
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Keywords
- Genital herpes
- HIV
- Stress
- Women
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Psychology(all)
Cite this
Stress as a predictor of symptomatic genetical herpes virus recurrence in women with human immunodeficiency virus. / Pereira, Deidre Byrnes; Antoni, Michael H; Danielson, Aimee; Simon, Trudi; Potter, JoNell E; Carver, Charles S; Durán, Ron E F; Ironson, Gail; Klimas, Nancy; Fletcher, Mary Ann; O'Sullivan, Mary Jo.
In: Journal of Psychosomatic Research, Vol. 54, No. 3, 01.03.2003, p. 237-244.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stress as a predictor of symptomatic genetical herpes virus recurrence in women with human immunodeficiency virus
AU - Pereira, Deidre Byrnes
AU - Antoni, Michael H
AU - Danielson, Aimee
AU - Simon, Trudi
AU - Potter, JoNell E
AU - Carver, Charles S
AU - Durán, Ron E F
AU - Ironson, Gail
AU - Klimas, Nancy
AU - Fletcher, Mary Ann
AU - O'Sullivan, Mary Jo
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Objective: Genital herpes (Herpes Simplex Virus Type 2, HSV-2) is a significant public health problem for HIV+ women, who have high rates of HSV-2 seropositivity and elevated risk for HSV-2 associated morbidity and mortality. Life stress has been identified as a co-factor in genital herpes recurrence. However, no research has evaluated the relationship between stress and genital herpes recurrences in HIV+ women. The purpose of this study was to determine whether stress was associated with symptomatic genital herpes recurrences in women seropositive for HIV and HSV-2. Methods: Thirty-four HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw and gynecologic examination to assess gynecologic symptoms (including genital herpes) at study entry. Life stress was measured using a 10-item modified version of the Life Experiences Survey (LES). Genital herpes recurrence over 1-year follow-up was abstracted using medical chart review. Results: Using hierarchical linear regression analysis, life stress at study entry was significantly associated with number of genital herpes recurrences during 1-year follow-up (β = .38, P =.03) after controlling for HIV disease variables and relevant behavioral factors. Recent life stress, in particular, was highly predictive of genital herpes recurrence during follow-up (β = .57, P= .002). The relationship between life stress and genital herpes recurrence persisted after controlling for HSV-2 viral reactivation (i.e., HSV-2 IgG titers) at study entry. Conclusion: These findings suggest that stress may be a significant predictor of genital herpes recurrence in women with HIV and HSV-2. Stress management interventions may buffer HSV-related morbidity and mortality in women with HIV.
AB - Objective: Genital herpes (Herpes Simplex Virus Type 2, HSV-2) is a significant public health problem for HIV+ women, who have high rates of HSV-2 seropositivity and elevated risk for HSV-2 associated morbidity and mortality. Life stress has been identified as a co-factor in genital herpes recurrence. However, no research has evaluated the relationship between stress and genital herpes recurrences in HIV+ women. The purpose of this study was to determine whether stress was associated with symptomatic genital herpes recurrences in women seropositive for HIV and HSV-2. Methods: Thirty-four HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw and gynecologic examination to assess gynecologic symptoms (including genital herpes) at study entry. Life stress was measured using a 10-item modified version of the Life Experiences Survey (LES). Genital herpes recurrence over 1-year follow-up was abstracted using medical chart review. Results: Using hierarchical linear regression analysis, life stress at study entry was significantly associated with number of genital herpes recurrences during 1-year follow-up (β = .38, P =.03) after controlling for HIV disease variables and relevant behavioral factors. Recent life stress, in particular, was highly predictive of genital herpes recurrence during follow-up (β = .57, P= .002). The relationship between life stress and genital herpes recurrence persisted after controlling for HSV-2 viral reactivation (i.e., HSV-2 IgG titers) at study entry. Conclusion: These findings suggest that stress may be a significant predictor of genital herpes recurrence in women with HIV and HSV-2. Stress management interventions may buffer HSV-related morbidity and mortality in women with HIV.
KW - Genital herpes
KW - HIV
KW - Stress
KW - Women
UR - http://www.scopus.com/inward/record.url?scp=0037349411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037349411&partnerID=8YFLogxK
U2 - 10.1016/S0022-3999(02)00494-4
DO - 10.1016/S0022-3999(02)00494-4
M3 - Article
C2 - 12614833
AN - SCOPUS:0037349411
VL - 54
SP - 237
EP - 244
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
SN - 0022-3999
IS - 3
ER -