Stress and psychiatric disorders

S. C. Stout, Charles Nemeroff

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Acute and/or chronic life stressors have long been postulated to play a role in the pathogenesis of numerous psychiatric diseases and in the exacerbation of symptoms. Some of the evidence from life events research supporting a link between stress and psychiatric disease is reviewed. The evidence that in general dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and specfically of corticotropin-releasing factor (CRF), the central mediator of the mammalian stress response, plays a pre-eminent role in the pathophysiology of mood and anxiety disorders is described.

Original languageEnglish
Pages (from-to)271-280
Number of pages10
JournalSeminars in the Neurosciences
Volume6
Issue number4
DOIs
StatePublished - Oct 25 1994
Externally publishedYes

Fingerprint

Psychiatry
Corticotropin-Releasing Hormone
Anxiety Disorders
Mood Disorders
Disease Progression
Research
tetraconazole

Keywords

  • Anxiety
  • Corticotropin-releasing factor
  • Depression
  • Neuropeptides
  • Post-traumatic stress disorder

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Stress and psychiatric disorders. / Stout, S. C.; Nemeroff, Charles.

In: Seminars in the Neurosciences, Vol. 6, No. 4, 25.10.1994, p. 271-280.

Research output: Contribution to journalArticle

Stout, S. C. ; Nemeroff, Charles. / Stress and psychiatric disorders. In: Seminars in the Neurosciences. 1994 ; Vol. 6, No. 4. pp. 271-280.
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