Stress and psychiatric disorders

Steven C. Stout, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Acute and/or chronic life stressors have long been postulated to play a role in the pathogenesis of numerous psychiatric diseases and in the exacerbation of symptoms. Some of the evidence from life events research supporting a link between stress and psychiatric disease is reviewed. The evidence that in general dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and specfically of corticotropin-releasing factor (CRF), the central mediator of the mammalian stress response, plays a pre-eminent role in the pathophysiology of mood and anxiety disorders is described.

Original languageEnglish (US)
Pages (from-to)271-280
Number of pages10
JournalSeminars in Neuroscience
Issue number4
StatePublished - Aug 1 1994
Externally publishedYes


  • Anxiety
  • Corticotropin-releasing factor
  • Depression
  • Neuropeptides
  • Post-traumatic stress disorder

ASJC Scopus subject areas

  • Neuroscience(all)


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