The brain and the immune system are the two major adaptive systems of the body. There is crosstalk between these two systems, which allows for maintaining homeostasis. here is a large body of evidence that documents the effects of stress on a variety of components of the immune response at the systemic level as well as cutaneous immunity. Stress can render the host more susceptible to bacterial infections and the development of cancer. Emotional stressors have been anecdotally linked to the development or exacerbation of a number of skin diseases (for example, acne, vitiligo, alopecia areata, lichen planus, seborrheic dermatitis, herpes infections). The role of stress in atopic dermatitis and psoriasis is well studied, and has established the adverse effects of stress on the clinical course of both diseases. There is definitely a brain-skin connection that can translate emotional stressors into biochemical mediators that can result in adverse effects on dermatologic diseases.
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