Streaming potential of human lumbar anulus fibrosus is anisotropic and affected by disc degeneration

W. Y. Gu, X. G. Mao, B. A. Rawlins, J. C. Iatridis, R. J. Foster, D. N. Sun, M. Weidenbaum, V. C. Mow

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

The streaming potential responses of non-degenerate and degenerate human anulus fibrosus were measured in a one-dimensional permeation configuration under static and dynamic loading conditions. The goal of this study was to investigate the influence of the changes in tissue structure and composition on the electrokinetic behavior of intervertebral disc tissues. It was found that the static streaming potential of the anulus fibrosus depended on the degenerative grade of the discs (p=0.0001) and on the specimen orientation in which the fluid flows (p=0.0001). For a statically applied pressure of 0.07MPa, the ratio of streaming potential to applied pressure ranged from 5.3 to 6.9mV/MPa and was largest for Grade I tissue with axial orientation and lowest for Grade III tissue with circumferential orientation. The dynamic streaming potential responses of anulus fibrosus were sensitive to the degeneration of the disc: the total harmonic distortion factor increased by 108%, from 3.92±0.66% (mean±SD) for Grade I specimens to 8.15±3.05% for Grades II and III specimens. The alteration of streaming potential reflects the changes in tissue composition and structure with degeneration. To our knowledge, this is the first reported data for the streaming potential of human intervertebral disc tissues. Knowledge of the streaming potential response of the intervertebral disc provides an understanding of potentially important signal transduction mechanisms in the disc and of the etiology of intervertebral disc degeneration. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)1177-1182
Number of pages6
JournalJournal of Biomechanics
Volume32
Issue number11
DOIs
StatePublished - Nov 1 1999

Keywords

  • Anulus fibrosus
  • Electrokinetic properties
  • Intervertebral disc
  • Soft tissue mechanics
  • Streaming potential

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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    Gu, W. Y., Mao, X. G., Rawlins, B. A., Iatridis, J. C., Foster, R. J., Sun, D. N., Weidenbaum, M., & Mow, V. C. (1999). Streaming potential of human lumbar anulus fibrosus is anisotropic and affected by disc degeneration. Journal of Biomechanics, 32(11), 1177-1182. https://doi.org/10.1016/S0021-9290(99)00118-9