Stratifying SLN incidence in intermediate thickness melanoma patients

James M. Chang, Heidi E. Kosiorek, Amylou C. Dueck, Stanley P.L. Leong, John T. Vetto, Richard L. White, Eli Avisar, Vernon K. Sondak, Jane L. Messina, Jonathan S. Zager, Carlos Garberoglio, Mohammed Kashani-Sabet, Barbara A. Pockaj

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Guidelines for melanoma recommend sentinel lymph node biopsy (SLNB) in patients with melanomas ≥1 mm thickness. Recent single institution studies have found tumors <1.5 mm a low-risk group for positive SLNB. Methods: A retrospective review of the Sentinel Lymph Node Working Group multicenter database identified patients with intermediate thickness melanoma (1.01–4.00 mm) who had SLNB, and assessed predictors for positive SLNB. Results: 3460 patients were analyzed, 584 (17%) had a positive SLNB. Univariate factors associated with a positive SLNB included age <60 (p <.001), tumor on the trunk/lower extremity (p <.001), Breslow depth ≥2 mm (p <.001), ulceration (p <.001), mitotic rate ≥1/mm2 (p =.01), and microsatellitosis (p <.001). Multivariate analysis revealed age, location, and Breslow depth as significant predictors. Patients ≥75 with lesions 1.01–1.49 mm on the head/neck/upper extremity and 1.5–1.99 mm without high-risk features had <5% risk of SLN positivity. Conclusions: Intermediate thickness melanoma has significant heterogeneity of SLNB positivity. Low-risk subgroups can be found among older patients in the absence of high-risk features.

Original languageEnglish (US)
JournalAmerican Journal of Surgery
DOIs
StateAccepted/In press - Jan 1 2018

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Sentinel Lymph Node Biopsy
Melanoma
Incidence
Upper Extremity
Lower Extremity
Neoplasms
Neck
Multivariate Analysis
Head
Databases
Guidelines

ASJC Scopus subject areas

  • Surgery

Cite this

Chang, J. M., Kosiorek, H. E., Dueck, A. C., Leong, S. P. L., Vetto, J. T., White, R. L., ... Pockaj, B. A. (Accepted/In press). Stratifying SLN incidence in intermediate thickness melanoma patients. American Journal of Surgery. https://doi.org/10.1016/j.amjsurg.2017.12.009

Stratifying SLN incidence in intermediate thickness melanoma patients. / Chang, James M.; Kosiorek, Heidi E.; Dueck, Amylou C.; Leong, Stanley P.L.; Vetto, John T.; White, Richard L.; Avisar, Eli; Sondak, Vernon K.; Messina, Jane L.; Zager, Jonathan S.; Garberoglio, Carlos; Kashani-Sabet, Mohammed; Pockaj, Barbara A.

In: American Journal of Surgery, 01.01.2018.

Research output: Contribution to journalArticle

Chang, JM, Kosiorek, HE, Dueck, AC, Leong, SPL, Vetto, JT, White, RL, Avisar, E, Sondak, VK, Messina, JL, Zager, JS, Garberoglio, C, Kashani-Sabet, M & Pockaj, BA 2018, 'Stratifying SLN incidence in intermediate thickness melanoma patients', American Journal of Surgery. https://doi.org/10.1016/j.amjsurg.2017.12.009
Chang, James M. ; Kosiorek, Heidi E. ; Dueck, Amylou C. ; Leong, Stanley P.L. ; Vetto, John T. ; White, Richard L. ; Avisar, Eli ; Sondak, Vernon K. ; Messina, Jane L. ; Zager, Jonathan S. ; Garberoglio, Carlos ; Kashani-Sabet, Mohammed ; Pockaj, Barbara A. / Stratifying SLN incidence in intermediate thickness melanoma patients. In: American Journal of Surgery. 2018.
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abstract = "Background: Guidelines for melanoma recommend sentinel lymph node biopsy (SLNB) in patients with melanomas ≥1 mm thickness. Recent single institution studies have found tumors <1.5 mm a low-risk group for positive SLNB. Methods: A retrospective review of the Sentinel Lymph Node Working Group multicenter database identified patients with intermediate thickness melanoma (1.01–4.00 mm) who had SLNB, and assessed predictors for positive SLNB. Results: 3460 patients were analyzed, 584 (17{\%}) had a positive SLNB. Univariate factors associated with a positive SLNB included age <60 (p <.001), tumor on the trunk/lower extremity (p <.001), Breslow depth ≥2 mm (p <.001), ulceration (p <.001), mitotic rate ≥1/mm2 (p =.01), and microsatellitosis (p <.001). Multivariate analysis revealed age, location, and Breslow depth as significant predictors. Patients ≥75 with lesions 1.01–1.49 mm on the head/neck/upper extremity and 1.5–1.99 mm without high-risk features had <5{\%} risk of SLN positivity. Conclusions: Intermediate thickness melanoma has significant heterogeneity of SLNB positivity. Low-risk subgroups can be found among older patients in the absence of high-risk features.",
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AU - Kosiorek, Heidi E.

AU - Dueck, Amylou C.

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AU - Vetto, John T.

AU - White, Richard L.

AU - Avisar, Eli

AU - Sondak, Vernon K.

AU - Messina, Jane L.

AU - Zager, Jonathan S.

AU - Garberoglio, Carlos

AU - Kashani-Sabet, Mohammed

AU - Pockaj, Barbara A.

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AB - Background: Guidelines for melanoma recommend sentinel lymph node biopsy (SLNB) in patients with melanomas ≥1 mm thickness. Recent single institution studies have found tumors <1.5 mm a low-risk group for positive SLNB. Methods: A retrospective review of the Sentinel Lymph Node Working Group multicenter database identified patients with intermediate thickness melanoma (1.01–4.00 mm) who had SLNB, and assessed predictors for positive SLNB. Results: 3460 patients were analyzed, 584 (17%) had a positive SLNB. Univariate factors associated with a positive SLNB included age <60 (p <.001), tumor on the trunk/lower extremity (p <.001), Breslow depth ≥2 mm (p <.001), ulceration (p <.001), mitotic rate ≥1/mm2 (p =.01), and microsatellitosis (p <.001). Multivariate analysis revealed age, location, and Breslow depth as significant predictors. Patients ≥75 with lesions 1.01–1.49 mm on the head/neck/upper extremity and 1.5–1.99 mm without high-risk features had <5% risk of SLN positivity. Conclusions: Intermediate thickness melanoma has significant heterogeneity of SLNB positivity. Low-risk subgroups can be found among older patients in the absence of high-risk features.

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