Strategies of human corneal endothelial tissue regeneration

Alfonso L. Sabater, Adriano Guarnieri, Edgar M. Espana, Wei Li, Felipe Prósper, Javier Moreno-Montañés

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Penetrating keratoplasty has previously been the only surgical treatment for patients with corneal endothelial disorders. Recently, posterior lamellar keratoplasty has become a viable and less aggressive alternative technique. However, both transplantation techniques have disadvantages, such as non-immunologic graft failure, allograft endothelial rejection or a global shortage of donor corneas. Over the past few years, several groups have established methods for the isolation, preservation, in vitro cultivation, transplantation, and in vivo stimulation of human corneal endothelial cells in animal models. It is hoped that these new strategies will allow the treatment of more than one patient with one donor cornea, performing autologous corneal endothelium transplantation from a surgical biopsy sample, or stimulating the growth of corneal endothelial cells in vivo. However, several aspects need to be addressed before commencing clinical trials.

Original languageEnglish (US)
Pages (from-to)183-195
Number of pages13
JournalRegenerative Medicine
Volume8
Issue number2
DOIs
StatePublished - Mar 2013
Externally publishedYes

Keywords

  • corneal endothelial dysfunction
  • corneal endothelial regeneration
  • corneal transplantation
  • tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

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