Strategies for Neuroprotection with Glutamate Antagonists: Extrapolating from Evidence Taken from the First Stroke and Head Injury Studies

R. BULLOCK

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Over fifty patients with severe head injury, and one hundred with stroke, have now been treated with the competitive NMDA antagonist CGS 19755 (selfotel). Preliminary analysis has shown possible evidence of benefit for both these clinical indications, and several other glutamate antagonists are now being evaluated for these indications in Phase II trials. The optimal dose of CGS 19755 (selfotel) for efficacy for severe head trauma has not yet been identified, but may be > 3 mg/kg, as at this dose there was evidence of an ICP lowering effect and improved CPP. For stroke, however, the maximal tolerated dose was 1.5 mg/kg, because these conscious patients developed hallucinations and agitation. There were no other significant drug-associated adverse events in either of these studies. It is difficult to determine the 'neuroprotective' dose for this compound in humans. By extrapolating from animal studies the 'best estimate' would be around 5 mg/kg in patients with severe head trauma. For stroke, behavioral side effects were the major limiting factor for dosing. Although several NMDA antagonists, including CGS 19755 (selfotel), are currently entering efficacy trials for stroke, based upon their tremendous potency in animal models, the problem of psychomimetric effects may necessitate the use of additional management strategies, e.g., more intensive monitoring and concomitant medications.

Original languageEnglish (US)
Pages (from-to)272-278
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume765
Issue number1
DOIs
StatePublished - Sep 1995

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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