Strategies for molecular intervention in esophageal cancers and their precursor lesions

D. S. Schrump, D. M. Nguyen

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Molecular analysis of malignant transformation in Barrett's epithelium provides insight into the temporal nature and significance of individual genetic events during multistep esophageal carcinogenesis. Potential targets for intervention in esophageal neoplasms include mutations involving retinoblastoma (Rb) and p53 tumor-suppressor pathways as well as tyrosine kinase cascades, which are known to promote cell cycle progression. Data from recent experiments provide the preclinical rationale for novel pharmacologic interventions in established esophageal cancers, and suggest strategies for chemoprevention in patients at risk for the development of these neoplasms.

Original languageEnglish (US)
Pages (from-to)181-185
Number of pages5
JournalDiseases of the Esophagus
Volume12
Issue number3
DOIs
StatePublished - Dec 1 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Gastroenterology

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