Strategies for molecular intervention in esophageal cancers and their precursor lesions

D. S. Schrump, Dao Nguyen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Molecular analysis of malignant transformation in Barrett's epithelium provides insight into the temporal nature and significance of individual genetic events during multistep esophageal carcinogenesis. Potential targets for intervention in esophageal neoplasms include mutations involving retinoblastoma (Rb) and p53 tumor-suppressor pathways as well as tyrosine kinase cascades, which are known to promote cell cycle progression. Data from recent experiments provide the preclinical rationale for novel pharmacologic interventions in established esophageal cancers, and suggest strategies for chemoprevention in patients at risk for the development of these neoplasms.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalDiseases of the Esophagus
Volume12
Issue number3
DOIs
StatePublished - Dec 1 1999
Externally publishedYes

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Esophageal Neoplasms
Barrett Esophagus
Retinoblastoma
Chemoprevention
Protein-Tyrosine Kinases
Neoplasms
Cell Cycle
Carcinogenesis
Mutation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Strategies for molecular intervention in esophageal cancers and their precursor lesions. / Schrump, D. S.; Nguyen, Dao.

In: Diseases of the Esophagus, Vol. 12, No. 3, 01.12.1999, p. 181-185.

Research output: Contribution to journalArticle

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