Strategies for genotype generation.

Simon Gregory, John Gilbert

Research output: Contribution to journalArticle

Abstract

The identification of genomic loci linked to human disease has been greatly facilitated by the evolution of genotyping strategies and techniques. The success of these strategies continues to be based upon clear clinical assessment, accurate sample handling, and careful data management, but also increasingly upon experimental design. Technological advances in the field of genotyping are permitting increasing complex population studies to be performed. An understanding of publicly available genetic variation databases, including an awareness of the limitations of these data, and an appreciation of the strategic approaches that should be used to exploit this information will provide tremendous insight for researchers are aiming to utilize this increasingly accessible technology. As single-nucleotide polymorphisms become the mainstay of genetic analyses, it is important that their source, distribution and de novo identification before understood before they are incorporated into genetic linkage and association analyses.

Original languageEnglish
JournalCurrent protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.]
VolumeChapter 1
StatePublished - Nov 1 2005
Externally publishedYes

Fingerprint

Genotyping Techniques
Genetic Databases
Genetic Linkage
Single Nucleotide Polymorphism
Research Design
Genotype
Research Personnel
Technology
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Strategies for genotype generation. / Gregory, Simon; Gilbert, John.

In: Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.], Vol. Chapter 1, 01.11.2005.

Research output: Contribution to journalArticle

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