Stitching up broken DNA ends by FANCA

Anna Palovcak, Wenjun Liu, Fenghua Yuan, Yanbin Zhang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

RAD52 rejoins resected broken DNA ends by mediating single-strand annealing. Our recent work elucidates that FANCA, a Fanconi anemia protein, also directly repairs double-strand breaks (DSBs) by catalyzing annealing of single-stranded DNA. FANCA and RAD52 likely play complementary roles to each other to prevent deleterious consequences of DSBs. Abbreviations: DSBs: DNA double-strand breaks; ICL: interstrand crosslink; ssDNA: single-stranded DNA; HR: homologous recombination; SSA: single-strand annealing; MMEJ: microhomology-mediated end joining; NHEJ: non-homologous end joining; GFP: green fluorescence protein.

Original languageEnglish (US)
Article numbere1518101
JournalMolecular and Cellular Oncology
Volume5
Issue number6
DOIs
StatePublished - Nov 2 2018

Keywords

  • FANCA
  • Fanconi anemia
  • double strand break repair
  • interstrand crosslink repair

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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