STING: Infection, inflammation and cancer

Research output: Contribution to journalReview article

294 Scopus citations

Abstract

The rapid detection of microbial agents is essential for the effective initiation of host defence mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger innate immune gene transcription has important implications-not only for comprehending the immune response to pathogens but also for elucidating the causes of autoinflammatory disease involving the sensing of self-DNA and the generation of effective antitumour adaptive immunity. The discovery of the STING (stimulator of interferon genes)-controlled innate immune pathway, which mediates cytosolic DNA-induced signalling events, has recently provided important insights into these processes, opening the way for the development of novel immunization regimes, as well as therapies to treat autoinflammatory disease and cancer.

Original languageEnglish (US)
Pages (from-to)760-770
Number of pages11
JournalNature Reviews Immunology
Volume15
Issue number12
DOIs
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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