STING: Infection, inflammation and cancer

Research output: Contribution to journalArticle

  • 136 Citations

Abstract

The rapid detection of microbial agents is essential for the effective initiation of host defence mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger innate immune gene transcription has important implications-not only for comprehending the immune response to pathogens but also for elucidating the causes of autoinflammatory disease involving the sensing of self-DNA and the generation of effective antitumour adaptive immunity. The discovery of the STING (stimulator of interferon genes)-controlled innate immune pathway, which mediates cytosolic DNA-induced signalling events, has recently provided important insights into these processes, opening the way for the development of novel immunization regimes, as well as therapies to treat autoinflammatory disease and cancer.

LanguageEnglish (US)
Pages760-770
Number of pages11
JournalNature Reviews Immunology
Volume15
Issue number12
DOIs
StatePublished - Dec 1 2015

Fingerprint

Interferons
Inflammation
DNA
Infection
Genes
Neoplasms
Adaptive Immunity
Immunization
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

STING : Infection, inflammation and cancer. / Barber, Glen N.

In: Nature Reviews Immunology, Vol. 15, No. 12, 01.12.2015, p. 760-770.

Research output: Contribution to journalArticle

@article{757faa54638a4bb3b8cb4a2683b1667f,
title = "STING: Infection, inflammation and cancer",
abstract = "The rapid detection of microbial agents is essential for the effective initiation of host defence mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger innate immune gene transcription has important implications-not only for comprehending the immune response to pathogens but also for elucidating the causes of autoinflammatory disease involving the sensing of self-DNA and the generation of effective antitumour adaptive immunity. The discovery of the STING (stimulator of interferon genes)-controlled innate immune pathway, which mediates cytosolic DNA-induced signalling events, has recently provided important insights into these processes, opening the way for the development of novel immunization regimes, as well as therapies to treat autoinflammatory disease and cancer.",
author = "Barber, {Glen N}",
year = "2015",
month = "12",
day = "1",
doi = "10.1038/nri3921",
language = "English (US)",
volume = "15",
pages = "760--770",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - STING

T2 - Nature Reviews Immunology

AU - Barber, Glen N

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The rapid detection of microbial agents is essential for the effective initiation of host defence mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger innate immune gene transcription has important implications-not only for comprehending the immune response to pathogens but also for elucidating the causes of autoinflammatory disease involving the sensing of self-DNA and the generation of effective antitumour adaptive immunity. The discovery of the STING (stimulator of interferon genes)-controlled innate immune pathway, which mediates cytosolic DNA-induced signalling events, has recently provided important insights into these processes, opening the way for the development of novel immunization regimes, as well as therapies to treat autoinflammatory disease and cancer.

AB - The rapid detection of microbial agents is essential for the effective initiation of host defence mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger innate immune gene transcription has important implications-not only for comprehending the immune response to pathogens but also for elucidating the causes of autoinflammatory disease involving the sensing of self-DNA and the generation of effective antitumour adaptive immunity. The discovery of the STING (stimulator of interferon genes)-controlled innate immune pathway, which mediates cytosolic DNA-induced signalling events, has recently provided important insights into these processes, opening the way for the development of novel immunization regimes, as well as therapies to treat autoinflammatory disease and cancer.

UR - http://www.scopus.com/inward/record.url?scp=84948670572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948670572&partnerID=8YFLogxK

U2 - 10.1038/nri3921

DO - 10.1038/nri3921

M3 - Article

VL - 15

SP - 760

EP - 770

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

IS - 12

ER -