Stimulation of Thyrotropin (TSH) Secretion by TSH-Releasing Factor (TRF) in Organ Cultures of Anterior Pituitary

J. C. Mittler; T. W. Redding; A. V. Schally

doi:10.3181/00379727-130-33566

Stimulation of Thyrotropin (TSH) Secretion by TSH-Releasing Factor (TRF) in Organ Cultures of Anterior Pituitary

J. C. Mittler, T. W. Redding, A. V. Schally

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Effects of pure TRF on male rat pituitary tissue were studied using standard organ culture techniques and chemically defined media. Addition of 40 pg of TRF caused increased TSH activity in both media and tissues, in comparison with controls. Under the conditions used, TRF seemed to stimulate the production of about 4 mU of TSH activity/pg of TRF used. This suggests that TRF can induce both the release and synthesis of TSH.

Original language	English (US)
Pages (from-to)	406-409
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	130
Issue number	2
DOIs	https://doi.org/10.3181/00379727-130-33566
State	Published - Feb 1969
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Stimulation of Thyrotropin (TSH) Secretion by TSH-Releasing Factor (TRF) in Organ Cultures of Anterior Pituitary",

abstract = "Effects of pure TRF on male rat pituitary tissue were studied using standard organ culture techniques and chemically defined media. Addition of 40 pg of TRF caused increased TSH activity in both media and tissues, in comparison with controls. Under the conditions used, TRF seemed to stimulate the production of about 4 mU of TSH activity/pg of TRF used. This suggests that TRF can induce both the release and synthesis of TSH.",

author = "Mittler, {J. C.} and Redding, {T. W.} and Schally, {A. V.}",

note = "Funding Information: Supported in part by USPHS Grant AM 07467 and by a Public Health Service Fellowship (AM 20. 071) from the National Institute of Arthritis and Metabolic Diseases. 2 1969 130 2 406 409 ",

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AU - Mittler, J. C.

AU - Redding, T. W.

AU - Schally, A. V.

N1 - Funding Information: Supported in part by USPHS Grant AM 07467 and by a Public Health Service Fellowship (AM 20. 071) from the National Institute of Arthritis and Metabolic Diseases. 2 1969 130 2 406 409

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AB - Effects of pure TRF on male rat pituitary tissue were studied using standard organ culture techniques and chemically defined media. Addition of 40 pg of TRF caused increased TSH activity in both media and tissues, in comparison with controls. Under the conditions used, TRF seemed to stimulate the production of about 4 mU of TSH activity/pg of TRF used. This suggests that TRF can induce both the release and synthesis of TSH.

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