Stimulation of Thyrotropin (TSH) Secretion by TSH-Releasing Factor (TRF) in Organ Cultures of Anterior Pituitary

J. C. Mittler, T. W. Redding, A. V. Schally

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Effects of pure TRF on male rat pituitary tissue were studied using standard organ culture techniques and chemically defined media. Addition of 40 pg of TRF caused increased TSH activity in both media and tissues, in comparison with controls. Under the conditions used, TRF seemed to stimulate the production of about 4 mU of TSH activity/pg of TRF used. This suggests that TRF can induce both the release and synthesis of TSH.

Original languageEnglish (US)
Pages (from-to)406-409
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume130
Issue number2
DOIs
StatePublished - Feb 1969
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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