Stimulation of Prolactin and Growth Hormone Release by TRH Infused into a Hypophysial Portal Vessel (38200)

Jiro Takahara, Akira Arimura, Andrew V. Schally

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The effects of infusion of synthetic thyrotropin releasing hormone (TRH) into a hypophysial portal vessel on the release of prolactin and growth hormone (GH) were investigated in normal male rats under urethane anesthesia. Significant increases in serum prolactin and GH levels were consistently observed after the infusion of 100 ng or larger doses of synthetic TRH, but smaller doses had no effect. Pretreatment of rats with 50 μg estradiol in oil raised the basal levels of prolactin and GH, but the net increase after TRH remained the same for prolactin and was somewhat reduced for GH.

Original languageEnglish (US)
Pages (from-to)831-835
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume146
Issue number3
DOIs
StatePublished - Jul 1974
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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