The effects of infusion of synthetic thyrotropin releasing hormone (TRH) into a hypophysial portal vessel on the release of prolactin and growth hormone (GH) were investigated in normal male rats under urethane anesthesia. Significant increases in serum prolactin and GH levels were consistently observed after the infusion of 100 ng or larger doses of synthetic TRH, but smaller doses had no effect. Pretreatment of rats with 50 μg estradiol in oil raised the basal levels of prolactin and GH, but the net increase after TRH remained the same for prolactin and was somewhat reduced for GH.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jul 1974|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)