Stimulation of luteinizing hormone (LH) and follicle stimulating hormone by [D Leu6,des Gly10 NH2] LH releasing hormone ethylamide after subcutaneous, intravaginal, and intrarectal administration to women

M. Saito, T. Kumasaki, Y. Yaoi, N. Nishi, A. Arimura, D. H. Coy, A. V. Schally

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Women, most of whom had regular menstrual cycles, were administered [D Leu 6, des Gly 10 NH 2] luteinizing hormone releasing hormone (LH RH) ethylamide (D Leu 6 LH RH EA) via different routes during the early or midfollicular phase of the cycle. Plasma LH, follicle stimulating hormone (FSH), and estrogen levels were determined by radioimmunoassay before and after administration of D Leu 6 LH RH EA. Plasma LH and FSH increased and reached peak levels 3 to 4 hr and 3 to 6 hr, respectively, after subcutaneous injection of 25 μg of the analog of LH RH. Intravaginal or intrarectal application of 2 mg of D Leu 6 LH RH EA also increased plasma LH and FSH levels in most of the women, but the magnitude of the rise, the time of initiation of response, and the peak level varied among the women. The plasma estrogen level also rose after administration via either route.

Original languageEnglish (US)
Pages (from-to)240-245
Number of pages6
JournalUnknown Journal
Volume28
Issue number3
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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