STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE

David Gonzalez-Barcena; M. Clinton Miller; David H. Coy; Abba J. Kastin; Don S. Schalch; Andrew V. Schally; Antonio Escalante-Herrera

doi:10.1016/S0140-6736(75)91009-0

STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE

David Gonzalez-Barcena, M. Clinton Miller, David H. Coy, Abba J. Kastin, Don S. Schalch, Andrew V. Schally, Antonio Escalante-Herrera

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

An analogue of luteinising-hormone-releasing hormone ([D-Leu-6, desGly- NH₂-10]-L.H.R.H.-ethylamide) was administered by mouth to thirteen healthy men. In eight men 10 mg of this superactive L.H.R.H. analogue significantly increased mean plasma-L.H. within 45 minutes of administration. This increase was sustained for more than 5 hours. 2 mg of the analogue did not significantly increase plasma-gonadotrophin concentrations in the five men to whom this smaller dose was given. Oral administration of some L.H.R.H. analogues would seem to be effective in releasing L.H. in man.

Original language	English (US)
Pages (from-to)	1126-1128
Number of pages	3
Journal	The Lancet
Volume	306
Issue number	7945
DOIs	https://doi.org/10.1016/S0140-6736(75)91009-0
State	Published - Dec 6 1975
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE. / Gonzalez-Barcena, David; Clinton Miller, M.; Coy, David H.; Kastin, Abba J.; Schalch, Don S.; Schally, Andrew V.; Escalante-Herrera, Antonio.

In: The Lancet, Vol. 306, No. 7945, 06.12.1975, p. 1126-1128.

Research output: Contribution to journal › Article › peer-review

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abstract = "An analogue of luteinising-hormone-releasing hormone ([D-Leu-6, desGly- NH2-10]-L.H.R.H.-ethylamide) was administered by mouth to thirteen healthy men. In eight men 10 mg of this superactive L.H.R.H. analogue significantly increased mean plasma-L.H. within 45 minutes of administration. This increase was sustained for more than 5 hours. 2 mg of the analogue did not significantly increase plasma-gonadotrophin concentrations in the five men to whom this smaller dose was given. Oral administration of some L.H.R.H. analogues would seem to be effective in releasing L.H. in man.",

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