Abstract
An analogue of luteinising-hormone-releasing hormone ([D-Leu-6, desGly- NH2-10]-L.H.R.H.-ethylamide) was administered by mouth to thirteen healthy men. In eight men 10 mg of this superactive L.H.R.H. analogue significantly increased mean plasma-L.H. within 45 minutes of administration. This increase was sustained for more than 5 hours. 2 mg of the analogue did not significantly increase plasma-gonadotrophin concentrations in the five men to whom this smaller dose was given. Oral administration of some L.H.R.H. analogues would seem to be effective in releasing L.H. in man.
Original language | English (US) |
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Pages (from-to) | 1126-1128 |
Number of pages | 3 |
Journal | The Lancet |
Volume | 306 |
Issue number | 7945 |
DOIs | |
State | Published - Dec 6 1975 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)