STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE

David Gonzalez-Barcena, M. Clinton Miller, DavidH Coy, AbbaJ Kastin, DonS Schalch, Andrew V Schally, Antonio Escalante-Herrera

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

An analogue of luteinising-hormone-releasing hormone ([D-Leu-6, desGly- NH2-10]-L.H.R.H.-ethylamide) was administered by mouth to thirteen healthy men. In eight men 10 mg of this superactive L.H.R.H. analogue significantly increased mean plasma-L.H. within 45 minutes of administration. This increase was sustained for more than 5 hours. 2 mg of the analogue did not significantly increase plasma-gonadotrophin concentrations in the five men to whom this smaller dose was given. Oral administration of some L.H.R.H. analogues would seem to be effective in releasing L.H. in man.

Original languageEnglish
Pages (from-to)1126-1128
Number of pages3
JournalThe Lancet
Volume306
Issue number7945
DOIs
StatePublished - Dec 6 1975
Externally publishedYes

Fingerprint

Luteinizing Hormone
Gonadotropin-Releasing Hormone
Oral Administration
Gonadotropins
Mouth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gonzalez-Barcena, D., Clinton Miller, M., Coy, D., Kastin, A., Schalch, D., Schally, A. V., & Escalante-Herrera, A. (1975). STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE. The Lancet, 306(7945), 1126-1128. https://doi.org/10.1016/S0140-6736(75)91009-0

STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE. / Gonzalez-Barcena, David; Clinton Miller, M.; Coy, DavidH; Kastin, AbbaJ; Schalch, DonS; Schally, Andrew V; Escalante-Herrera, Antonio.

In: The Lancet, Vol. 306, No. 7945, 06.12.1975, p. 1126-1128.

Research output: Contribution to journal › Article

Gonzalez-Barcena, D, Clinton Miller, M, Coy, D, Kastin, A, Schalch, D, Schally, AV & Escalante-Herrera, A 1975, 'STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE', The Lancet, vol. 306, no. 7945, pp. 1126-1128. https://doi.org/10.1016/S0140-6736(75)91009-0
Gonzalez-Barcena D, Clinton Miller M, Coy D, Kastin A, Schalch D, Schally AV et al. STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE. The Lancet. 1975 Dec 6;306(7945):1126-1128. https://doi.org/10.1016/S0140-6736(75)91009-0
Gonzalez-Barcena, David ; Clinton Miller, M. ; Coy, DavidH ; Kastin, AbbaJ ; Schalch, DonS ; Schally, Andrew V ; Escalante-Herrera, Antonio. / STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE. In: The Lancet. 1975 ; Vol. 306, No. 7945. pp. 1126-1128.
@article{5a87c81702e34ffe979a24e1e1fb1fa7,
title = "STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE",
abstract = "An analogue of luteinising-hormone-releasing hormone ([D-Leu-6, desGly- NH2-10]-L.H.R.H.-ethylamide) was administered by mouth to thirteen healthy men. In eight men 10 mg of this superactive L.H.R.H. analogue significantly increased mean plasma-L.H. within 45 minutes of administration. This increase was sustained for more than 5 hours. 2 mg of the analogue did not significantly increase plasma-gonadotrophin concentrations in the five men to whom this smaller dose was given. Oral administration of some L.H.R.H. analogues would seem to be effective in releasing L.H. in man.",
author = "David Gonzalez-Barcena and {Clinton Miller}, M. and DavidH Coy and AbbaJ Kastin and DonS Schalch and Schally, {Andrew V} and Antonio Escalante-Herrera",
year = "1975",
month = "12",
day = "6",
doi = "10.1016/S0140-6736(75)91009-0",
language = "English",
volume = "306",
pages = "1126--1128",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "7945",

}

TY - JOUR

T1 - STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE

AU - Gonzalez-Barcena, David

AU - Clinton Miller, M.

AU - Coy, DavidH

AU - Kastin, AbbaJ

AU - Schalch, DonS

AU - Schally, Andrew V

AU - Escalante-Herrera, Antonio

PY - 1975/12/6

Y1 - 1975/12/6

N2 - An analogue of luteinising-hormone-releasing hormone ([D-Leu-6, desGly- NH2-10]-L.H.R.H.-ethylamide) was administered by mouth to thirteen healthy men. In eight men 10 mg of this superactive L.H.R.H. analogue significantly increased mean plasma-L.H. within 45 minutes of administration. This increase was sustained for more than 5 hours. 2 mg of the analogue did not significantly increase plasma-gonadotrophin concentrations in the five men to whom this smaller dose was given. Oral administration of some L.H.R.H. analogues would seem to be effective in releasing L.H. in man.

AB - An analogue of luteinising-hormone-releasing hormone ([D-Leu-6, desGly- NH2-10]-L.H.R.H.-ethylamide) was administered by mouth to thirteen healthy men. In eight men 10 mg of this superactive L.H.R.H. analogue significantly increased mean plasma-L.H. within 45 minutes of administration. This increase was sustained for more than 5 hours. 2 mg of the analogue did not significantly increase plasma-gonadotrophin concentrations in the five men to whom this smaller dose was given. Oral administration of some L.H.R.H. analogues would seem to be effective in releasing L.H. in man.

UR - http://www.scopus.com/inward/record.url?scp=0016775838&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016775838&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(75)91009-0

DO - 10.1016/S0140-6736(75)91009-0

M3 - Article

C2 - 53605

AN - SCOPUS:0016775838

VL - 306

SP - 1126

EP - 1128

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 7945

ER -

Access to Document