STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE

David Gonzalez-Barcena, M. Clinton Miller, David H. Coy, Abba J. Kastin, Don S. Schalch, Andrew V. Schally, Antonio Escalante-Herrera

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

An analogue of luteinising-hormone-releasing hormone ([D-Leu-6, desGly- NH2-10]-L.H.R.H.-ethylamide) was administered by mouth to thirteen healthy men. In eight men 10 mg of this superactive L.H.R.H. analogue significantly increased mean plasma-L.H. within 45 minutes of administration. This increase was sustained for more than 5 hours. 2 mg of the analogue did not significantly increase plasma-gonadotrophin concentrations in the five men to whom this smaller dose was given. Oral administration of some L.H.R.H. analogues would seem to be effective in releasing L.H. in man.

Original languageEnglish (US)
Pages (from-to)1126-1128
Number of pages3
JournalThe Lancet
Volume306
Issue number7945
DOIs
StatePublished - Dec 6 1975
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Gonzalez-Barcena, D., Clinton Miller, M., Coy, D. H., Kastin, A. J., Schalch, D. S., Schally, A. V., & Escalante-Herrera, A. (1975). STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE. The Lancet, 306(7945), 1126-1128. https://doi.org/10.1016/S0140-6736(75)91009-0