Abstract
A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.
| Original language | English |
|---|---|
| Pages (from-to) | 252-256 |
| Number of pages | 5 |
| Journal | FEBS Letters |
| Volume | 179 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 7 1985 |
| Externally published | Yes |
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Keywords
- Dephosphorylationl
- EGF
- EGF receptor
- Pancreatic cancer Growth control
- Somatostatin
- Somatostatin receptor
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line. / Hierowski, Marion T.; Liebow, Charles; du Sapin, Karen; Schally, Andrew V.
In: FEBS Letters, Vol. 179, No. 2, 07.01.1985, p. 252-256.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line
AU - Hierowski, Marion T.
AU - Liebow, Charles
AU - du Sapin, Karen
AU - Schally, Andrew V
PY - 1985/1/7
Y1 - 1985/1/7
N2 - A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.
AB - A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.
KW - Dephosphorylationl
KW - EGF
KW - EGF receptor
KW - Pancreatic cancer Growth control
KW - Somatostatin
KW - Somatostatin receptor
UR - http://www.scopus.com/inward/record.url?scp=0021992874&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021992874&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(85)80529-9
DO - 10.1016/0014-5793(85)80529-9
M3 - Article
VL - 179
SP - 252
EP - 256
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 2
ER -