Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line

Marion T. Hierowski; Charles Liebow; Karen du Sapin; Andrew V. Schally

doi:10.1016/0014-5793(85)80529-9

Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line

Marion T. Hierowski, Charles Liebow, Karen du Sapin, Andrew V. Schally

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.

Original language	English (US)
Pages (from-to)	252-256
Number of pages	5
Journal	FEBS letters
Volume	179
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(85)80529-9
State	Published - Jan 7 1985
Externally published	Yes

Keywords

Dephosphorylationl
EGF
EGF receptor
Pancreatic cancer Growth control
Somatostatin
Somatostatin receptor

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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title = "Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line",

abstract = "A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.",

keywords = "Dephosphorylationl, EGF, EGF receptor, Pancreatic cancer Growth control, Somatostatin, Somatostatin receptor",

author = "Hierowski, {Marion T.} and Charles Liebow and {du Sapin}, Karen and Schally, {Andrew V.}",

note = "Funding Information: ACKNOWLEDGEMENT This work wass upportedin part by a grantf rom the SchliederF oundation.",

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T1 - Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line

AU - Hierowski, Marion T.

AU - Liebow, Charles

AU - du Sapin, Karen

AU - Schally, Andrew V.

N1 - Funding Information: ACKNOWLEDGEMENT This work wass upportedin part by a grantf rom the SchliederF oundation.

PY - 1985/1/7

Y1 - 1985/1/7

N2 - A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.

AB - A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.

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KW - EGF

KW - EGF receptor

KW - Pancreatic cancer Growth control

KW - Somatostatin

KW - Somatostatin receptor

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