Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line

Marion T. Hierowski; Charles Liebow; Karen du Sapin; Andrew V. Schally

doi:10.1016/0014-5793(85)80529-9

Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line

Marion T. Hierowski, Charles Liebow, Karen du Sapin, Andrew V. Schally

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.

Original language	English (US)
Pages (from-to)	252-256
Number of pages	5
Journal	FEBS letters
Volume	179
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(85)80529-9
State	Published - Jan 7 1985
Externally published	Yes

Keywords

Dephosphorylationl
EGF
EGF receptor
Pancreatic cancer Growth control
Somatostatin
Somatostatin receptor

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0014-5793(85)80529-9

Cite this

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title = "Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line",

abstract = "A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.",

keywords = "Dephosphorylationl, EGF, EGF receptor, Pancreatic cancer Growth control, Somatostatin, Somatostatin receptor",

author = "Hierowski, {Marion T.} and Charles Liebow and {du Sapin}, Karen and Schally, {Andrew V.}",

note = "Funding Information: ACKNOWLEDGEMENT This work wass upportedin part by a grantf rom the SchliederF oundation.",

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doi = "10.1016/0014-5793(85)80529-9",

language = "English (US)",

volume = "179",

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TY - JOUR

T1 - Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line

AU - Hierowski, Marion T.

AU - Liebow, Charles

AU - du Sapin, Karen

AU - Schally, Andrew V.

N1 - Funding Information: ACKNOWLEDGEMENT This work wass upportedin part by a grantf rom the SchliederF oundation.

PY - 1985/1/7

Y1 - 1985/1/7

N2 - A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.

AB - A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.

KW - Dephosphorylationl

KW - EGF

KW - EGF receptor

KW - Pancreatic cancer Growth control

KW - Somatostatin

KW - Somatostatin receptor

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DO - 10.1016/0014-5793(85)80529-9

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JO - FEBS Letters

JF - FEBS Letters

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Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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