Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line

Marion T. Hierowski; Charles Liebow; Karen du Sapin; Andrew V. Schally

doi:10.1016/0014-5793(85)80529-9

Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line

Marion T. Hierowski, Charles Liebow, Karen du Sapin, Andrew V. Schally

Research output: Contribution to journal › Article

110 Scopus citations

Abstract

A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.

Original language	English (US)
Pages (from-to)	252-256
Number of pages	5
Journal	FEBS letters
Volume	179
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(85)80529-9
State	Published - Jan 7 1985
Externally published	Yes

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Keywords

Dephosphorylationl
EGF
EGF receptor
Pancreatic cancer Growth control
Somatostatin
Somatostatin receptor

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Cite this

Hierowski, M. T., Liebow, C., du Sapin, K., & Schally, A. V. (1985). Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line. FEBS letters, 179(2), 252-256. https://doi.org/10.1016/0014-5793(85)80529-9

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10.1016/0014-5793(85)80529-9