Abstract
A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.
Original language | English (US) |
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Pages (from-to) | 252-256 |
Number of pages | 5 |
Journal | FEBS letters |
Volume | 179 |
Issue number | 2 |
DOIs | |
State | Published - Jan 7 1985 |
Externally published | Yes |
Keywords
- Dephosphorylationl
- EGF
- EGF receptor
- Pancreatic cancer Growth control
- Somatostatin
- Somatostatin receptor
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology