Abstract
A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 252-256 |
| Number of pages | 5 |
| Journal | FEBS letters |
| Volume | 179 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 7 1985 |
| Externally published | Yes |
Keywords
- Dephosphorylationl
- EGF
- EGF receptor
- Pancreatic cancer Growth control
- Somatostatin
- Somatostatin receptor
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Cite this
Hierowski, M. T., Liebow, C., du Sapin, K., & Schally, A. V. (1985). Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line. FEBS letters, 179(2), 252-256. https://doi.org/10.1016/0014-5793(85)80529-9