Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line

Marion T. Hierowski, Charles Liebow, Karen du Sapin, Andrew V. Schally

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.

Original languageEnglish (US)
Pages (from-to)252-256
Number of pages5
JournalFEBS letters
Volume179
Issue number2
DOIs
StatePublished - Jan 7 1985
Externally publishedYes

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Keywords

  • Dephosphorylationl
  • EGF
  • EGF receptor
  • Pancreatic cancer Growth control
  • Somatostatin
  • Somatostatin receptor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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