Stimulant-like effects of magnesium on aggression in mice

Sari E Izenwasser, Katia Garcia-Valdez, Kathleen M. Kantak

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The effects of magnesium excesses resulting from daily injections of magnesium chloride (MgCl2) were examined on offensive behavior in a resident-intruder situation. Male mice tested 5 min post-injection of 15 mg/kg or 30 mg/kg exhibited a significantly greater number of attacks and threats than saline controls; while in mice injected with 125 mg/kg threat and attack behaviors were decreased. No tolerance developed to this decrease which persisted throughout the 15 day injection period. Tolerance to the aggression enhancing effects developed in the 30 mg/kg group which returned to normal by Day 4 and in the 15 mg/kg group which returned to normal by Day 15. Two weeks following the last injection, all groups performed equally. When mice were tested prior to daily injections on Days 4, 8, and 15 in a second experiment, there were no MgCl2 dose differences in threat or attack behavior, thus there was no cumulative effect of MgCl2 on behavior. These data and our previous data showing that MgCl2 deficiencies reduce offensive aggression suggest an inverted U-shape function to magnesium's influence on behavior. Since aggression has been linked to the neurotransmitters dopamine, norepinephrine, and serotonin, and magnesium has been shown to be an important cofactor in the activity of these neurotransmitters, it is possible that the effects seen here are related to changes in one or more of these systems.

Original languageEnglish
Pages (from-to)1195-1199
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume25
Issue number6
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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Magnesium Chloride
Aggression
Magnesium
Injections
Neurotransmitter Agents
Dopamine
Serotonin
Norepinephrine
Experiments

Keywords

  • Acute administration
  • Aggression
  • Chronic administration
  • Magnesium
  • Stimulant

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Stimulant-like effects of magnesium on aggression in mice. / Izenwasser, Sari E; Garcia-Valdez, Katia; Kantak, Kathleen M.

In: Pharmacology, Biochemistry and Behavior, Vol. 25, No. 6, 01.01.1986, p. 1195-1199.

Research output: Contribution to journalArticle

Izenwasser, Sari E ; Garcia-Valdez, Katia ; Kantak, Kathleen M. / Stimulant-like effects of magnesium on aggression in mice. In: Pharmacology, Biochemistry and Behavior. 1986 ; Vol. 25, No. 6. pp. 1195-1199.
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