Stewart-Treves Syndrome: A Case Report and Review of the Literature

Roberto Berebichez-Fridman, Yehuda E. Deutsch, Thomas M. Joyal, Pablo Montero Olvera, Pasquale W Benedetto, Andrew Rosenberg, Daniel H Kett

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The Stewart-Treves syndrome is a rare and deadly entity, which is defined as angiosarcoma arising in the setting of chronic lymphedema. It typically presents in women who develop lymphedema in the upper extremity secondary to axillary lymph node dissection for breast cancer surgery. It is extremely uncommon in the lower extremities as a result of idiopathic chronic lymphedema. Here, we present the case of a 63-year-old female patient with idiopathic chronic lymphedema of the lower extremities having morbid obesity (BMI 82.6) and multiple comorbidities. She developed multiple confluent, hemorrhagic and necrotic elevated purple-black papules in the lower extremities, for which the initial diagnosis was cellulitis. Because there was no improvement with antibiotics, a lower extremity ultrasound and biopsy was performed which showed multiple masses in the left inner upper calf with solid and cystic components. The pathology results of the punch biopsies were consistent with angiosarcoma. Immunohistochemical studies revealed positivity for CD31, FLI-1, and a high Ki-67 proliferation rate. Because of the patient's weight and medical comorbidities, no further extensive diagnostic tests were performed to detect metastatic disease, and because of contraindications, no further medical treatment was provided. The patient subsequently died 1 month after diagnosis.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalCase Reports in Oncology
DOIs
StateAccepted/In press - Apr 1 2016

Fingerprint

Lymphedema
Lower Extremity
Hemangiosarcoma
Comorbidity
Biopsy
Cellulitis
Morbid Obesity
Lymph Node Excision
Routine Diagnostic Tests
Upper Extremity
Pathology
Breast Neoplasms
Anti-Bacterial Agents
Weights and Measures
Stewart Treves syndrome
Therapeutics

Keywords

  • Angiosarcoma
  • Cancer
  • Diagnosis
  • Lymphedema
  • Morbid obesity
  • Stewart-Treves syndrome
  • Treatment#

ASJC Scopus subject areas

  • Oncology

Cite this

Stewart-Treves Syndrome : A Case Report and Review of the Literature. / Berebichez-Fridman, Roberto; Deutsch, Yehuda E.; Joyal, Thomas M.; Montero Olvera, Pablo; Benedetto, Pasquale W; Rosenberg, Andrew; Kett, Daniel H.

In: Case Reports in Oncology, 01.04.2016, p. 205-211.

Research output: Contribution to journalArticle

Berebichez-Fridman, Roberto ; Deutsch, Yehuda E. ; Joyal, Thomas M. ; Montero Olvera, Pablo ; Benedetto, Pasquale W ; Rosenberg, Andrew ; Kett, Daniel H. / Stewart-Treves Syndrome : A Case Report and Review of the Literature. In: Case Reports in Oncology. 2016 ; pp. 205-211.
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