Steroid-induced diabetes: A clinical and molecular approach to understanding and treatment

Jessica L. Hwang, Roy E. Weiss

Research output: Contribution to journalReview article

87 Scopus citations

Abstract

Since the advent of glucocorticoid therapy for autoimmune disease in the 1940s, their widespread application has led to the concurrent therapy-limiting discovery of many adverse metabolic side effects. Unanticipated hyperglycemia associated with the initiation of glucocorticoids often leads to preventable hospital admissions, prolonged hospital stays, increased risks for infection and reduced graft function in solid organ transplant recipients. Challenges in managing steroid-induced diabetes stem from wide fluctuations in post-prandial hyperglycemia and the lack of clearly defined treatment protocols. The mainstay of treatment is insulin therapy coincident with meals. This article aims to review the pathogenesis, risk factors, diagnosis and treatment principles unique to steroid-induced diabetes.

Original languageEnglish (US)
Pages (from-to)96-102
Number of pages7
JournalDiabetes/Metabolism Research and Reviews
Volume30
Issue number2
DOIs
StatePublished - Feb 1 2014
Externally publishedYes

Keywords

  • Glucocorticoids
  • Insulin resistance
  • New onset diabetes after transplant
  • Steroid-induced diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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