Steroid hormone receptors in human colon cancers

T. Crandall Alford, Hoan‐My ‐M Do, Glenn W. Geelhoed, Neofytos T. Tsangaris, Marc E. Lippman

Research output: Contribution to journalArticle

137 Scopus citations

Abstract

Tumors from patients with primary colon cancer were studied for the presence of steroid hormone receptor for estrogen (E 2), progesterone (Prog), dihydrotestosterone (DHT) and glucocorticoid. Ten of 33 (30%) tumors contained high affinity E 2 receptors. Four were males and six females with positive assays predominantly from the left colon. Twenty-three of these tumors were also assayed for DHT and Prog and six (26%) contained all three receptors. An additional twelve tumors had at least one receptor, so that 70% of the tumors studied contained one or more receptors. Five of 22 (23%) samples were positive for glucocorticoid receptors. Common etiological factors associated with colon and breast cancer were briefly discussed. These factors, along with the presence of hormone receptors in primary colon malignancies suggest that some large bowel cancers may be endocrine-dependent.

Original languageEnglish (US)
Pages (from-to)980-984
Number of pages5
JournalCancer
Volume43
Issue number3
DOIs
StatePublished - Mar 1979

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Alford, T. C., Do, HM. M., Geelhoed, G. W., Tsangaris, N. T., & Lippman, M. E. (1979). Steroid hormone receptors in human colon cancers. Cancer, 43(3), 980-984. https://doi.org/10.1002/1097-0142(197903)43:3<980::AID-CNCR2820430329>3.0.CO;2-R