Steric and electronic effects in capsule-confined green fluorescent protein chromophores

Anthony Baldridge, Shampa R. Samanta, Nithyanandhan Jayaraj, Vaidhyanathan Ramamurthy, Laren M. Tolbert

Research output: Contribution to journalArticle

56 Scopus citations


The turn-on of emission in fluorescent protein chromophores sequestered in an "octaacid" capsule is controlled by stereoelectronic effects described by a linear free energy relationship. The stereochemical effects are governed by both the positions and volumes of the aryl substituents, while the electronic effects, including ortho effects, can be treated with Hammett σ parameters. The use of substituent volumes rather than A values reflects packing of the molecule within the confines of the capsule.

Original languageEnglish
Pages (from-to)712-715
Number of pages4
JournalJournal of the American Chemical Society
Issue number4
StatePublished - Feb 2 2011


ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

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