Steric and electronic effects in capsule-confined green fluorescent protein chromophores

Anthony Baldridge, Shampa R. Samanta, Nithyanandhan Jayaraj, V. Ramamurthy, Laren M. Tolbert

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


The turn-on of emission in fluorescent protein chromophores sequestered in an "octaacid" capsule is controlled by stereoelectronic effects described by a linear free energy relationship. The stereochemical effects are governed by both the positions and volumes of the aryl substituents, while the electronic effects, including ortho effects, can be treated with Hammett σ parameters. The use of substituent volumes rather than A values reflects packing of the molecule within the confines of the capsule.

Original languageEnglish (US)
Pages (from-to)712-715
Number of pages4
JournalJournal of the American Chemical Society
Issue number4
StatePublished - Feb 2 2011

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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