Stereotactic uses beyond core biopsy: Model development for minimally invasive treatment of breast cancer through interstitial laser hyperthermia

David S. Robinson, Jean-Marie A Parel, David B. Denham, Fabrice Manns, Xochitl Gonzalez, Robert Schachner, Alan Herron, Everett C. Burdette

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Light of a Nd:YAG laser presented through a fiberoptic cable to a diffusing tip can be adapted to mammographic stereotactic instruments now used for core biopsy in the hyperthermic endoablation of breast cancer. This approach to cancer destruction extends breast preservation to the point of no observable surface skin change. The initial analysis characterizes the effects of laser endohyperthermia in a physical model as well as in tissue, both ex vivo and in vivo, to create a reliable technique that will lead to human trials. A fiberoptic cable with a diffusing quartz tip placed deep within soft tissue can pass light of a neodymium laser and consequent thermal energy for the destruction of surrounding soft tissues. Because breast cancer occurs with greatest frequency in the involuted breasts of women more than 50 years of age and because this tissue is predominantly fibro-fatty in nature, our work has concentrated on model development and the determination of heat distribution and destruction of fat and fibro-fatty tissue. Following the development of a physical model, time-temperature courses were found to be similar in ex vivo human breast tissue and subcutaneous porcine fat. This led to in vivo porcine studies that confirmed similar time-temperature courses. For tissues brought to a range of 60°C to 80°C and sustained for the better part of 20 minutes, gross and histological analyses reveal complete destruction over a 1 1/2 cm radial region around the laser tip. This approach offers great promise for the treatment of stereotactically biopsied small T1 breast carcinomas.

Original languageEnglish
Pages (from-to)117-118
Number of pages2
JournalAmerican Surgeon
Volume62
Issue number2
StatePublished - Feb 1 1996

Fingerprint

Lasers
Fever
Breast Neoplasms
Biopsy
Breast
Swine
Therapeutics
Incineration
Neodymium
Light
Quartz
Temperature
Subcutaneous Fat
Solid-State Lasers
Adipose Tissue
Hot Temperature
Fats
Skin
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Stereotactic uses beyond core biopsy : Model development for minimally invasive treatment of breast cancer through interstitial laser hyperthermia. / Robinson, David S.; Parel, Jean-Marie A; Denham, David B.; Manns, Fabrice; Gonzalez, Xochitl; Schachner, Robert; Herron, Alan; Burdette, Everett C.

In: American Surgeon, Vol. 62, No. 2, 01.02.1996, p. 117-118.

Research output: Contribution to journalArticle

Robinson, David S. ; Parel, Jean-Marie A ; Denham, David B. ; Manns, Fabrice ; Gonzalez, Xochitl ; Schachner, Robert ; Herron, Alan ; Burdette, Everett C. / Stereotactic uses beyond core biopsy : Model development for minimally invasive treatment of breast cancer through interstitial laser hyperthermia. In: American Surgeon. 1996 ; Vol. 62, No. 2. pp. 117-118.
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