Stereotactic radiosurgery: Adjacent tissue injury and response after high-dose single fraction radiation-part II: Strategies for therapeutic enhancement, brain injury mitigation, and brain injury repair

Bryan C. Oh, Charles Y. Liu, Michael Y. Wang, Paul G. Pagnini, Cheng Yu, Michael L J Apuzzo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

IN THE FIRST part of this series, we reviewed the histological, radiographic, and molecular data gathered regarding the brain parenchymal response to radiosurgery and suggested future studies that could enhance our understanding of the topic. With this article, we begin by addressing methods of potentiating the effect of radiosurgery on target lesions of the central nervous system. Much of the work on potentiating the effects of cranial radiation has been performed in the field of whole-brain radiotherapy. Data from Phase III trials evaluating the efficacy of various agents as radiosensitizers or radioenhancers in whole-brain radiotherapy are reviewed, and trials for investigating certain agents as enhancers of radiosurgery are suggested. The roles of gene therapy and nanotechnology in enhancing the therapeutic efficacy of radiosurgery are then addressed. Focus is then shifted to a discussion of strategies of protecting healthy tissue from the potentially deleterious aspects of the brain's response to radiosurgery that were presented in the first article of this series. Finally, comments are made regarding the role of neural progenitor or stem cells in the repair of radiation-induced brain injury after radiosurgery. The importance of both the role of the extracellular matrix and properly directed axonal regrowth leading to appropriate target reinnervation is highlighted.

Original languageEnglish
Pages (from-to)799-813
Number of pages15
JournalNeurosurgery
Volume60
Issue number5
DOIs
StatePublished - May 1 2007
Externally publishedYes

Fingerprint

Radiosurgery
Brain Injuries
Radiation
Wounds and Injuries
Brain
Radiotherapy
Stem Cells
Therapeutics
Nanotechnology
Radiation Effects
Genetic Therapy
Extracellular Matrix
Central Nervous System

Keywords

  • Radiation enhancement
  • Radiation injury
  • Radiation potentiation
  • Radiation protection
  • Radiation repair
  • Radiosensitizer
  • Radiosurgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Stereotactic radiosurgery : Adjacent tissue injury and response after high-dose single fraction radiation-part II: Strategies for therapeutic enhancement, brain injury mitigation, and brain injury repair. / Oh, Bryan C.; Liu, Charles Y.; Wang, Michael Y.; Pagnini, Paul G.; Yu, Cheng; Apuzzo, Michael L J.

In: Neurosurgery, Vol. 60, No. 5, 01.05.2007, p. 799-813.

Research output: Contribution to journalArticle

Oh, Bryan C. ; Liu, Charles Y. ; Wang, Michael Y. ; Pagnini, Paul G. ; Yu, Cheng ; Apuzzo, Michael L J. / Stereotactic radiosurgery : Adjacent tissue injury and response after high-dose single fraction radiation-part II: Strategies for therapeutic enhancement, brain injury mitigation, and brain injury repair. In: Neurosurgery. 2007 ; Vol. 60, No. 5. pp. 799-813.
@article{a5149c704cb64439bf0428055085532a,
title = "Stereotactic radiosurgery: Adjacent tissue injury and response after high-dose single fraction radiation-part II: Strategies for therapeutic enhancement, brain injury mitigation, and brain injury repair",
abstract = "IN THE FIRST part of this series, we reviewed the histological, radiographic, and molecular data gathered regarding the brain parenchymal response to radiosurgery and suggested future studies that could enhance our understanding of the topic. With this article, we begin by addressing methods of potentiating the effect of radiosurgery on target lesions of the central nervous system. Much of the work on potentiating the effects of cranial radiation has been performed in the field of whole-brain radiotherapy. Data from Phase III trials evaluating the efficacy of various agents as radiosensitizers or radioenhancers in whole-brain radiotherapy are reviewed, and trials for investigating certain agents as enhancers of radiosurgery are suggested. The roles of gene therapy and nanotechnology in enhancing the therapeutic efficacy of radiosurgery are then addressed. Focus is then shifted to a discussion of strategies of protecting healthy tissue from the potentially deleterious aspects of the brain's response to radiosurgery that were presented in the first article of this series. Finally, comments are made regarding the role of neural progenitor or stem cells in the repair of radiation-induced brain injury after radiosurgery. The importance of both the role of the extracellular matrix and properly directed axonal regrowth leading to appropriate target reinnervation is highlighted.",
keywords = "Radiation enhancement, Radiation injury, Radiation potentiation, Radiation protection, Radiation repair, Radiosensitizer, Radiosurgery",
author = "Oh, {Bryan C.} and Liu, {Charles Y.} and Wang, {Michael Y.} and Pagnini, {Paul G.} and Cheng Yu and Apuzzo, {Michael L J}",
year = "2007",
month = "5",
day = "1",
doi = "10.1227/01.NEU.0000255454.28225.5C",
language = "English",
volume = "60",
pages = "799--813",
journal = "Neurosurgery",
issn = "0148-396X",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Stereotactic radiosurgery

T2 - Adjacent tissue injury and response after high-dose single fraction radiation-part II: Strategies for therapeutic enhancement, brain injury mitigation, and brain injury repair

AU - Oh, Bryan C.

AU - Liu, Charles Y.

AU - Wang, Michael Y.

AU - Pagnini, Paul G.

AU - Yu, Cheng

AU - Apuzzo, Michael L J

PY - 2007/5/1

Y1 - 2007/5/1

N2 - IN THE FIRST part of this series, we reviewed the histological, radiographic, and molecular data gathered regarding the brain parenchymal response to radiosurgery and suggested future studies that could enhance our understanding of the topic. With this article, we begin by addressing methods of potentiating the effect of radiosurgery on target lesions of the central nervous system. Much of the work on potentiating the effects of cranial radiation has been performed in the field of whole-brain radiotherapy. Data from Phase III trials evaluating the efficacy of various agents as radiosensitizers or radioenhancers in whole-brain radiotherapy are reviewed, and trials for investigating certain agents as enhancers of radiosurgery are suggested. The roles of gene therapy and nanotechnology in enhancing the therapeutic efficacy of radiosurgery are then addressed. Focus is then shifted to a discussion of strategies of protecting healthy tissue from the potentially deleterious aspects of the brain's response to radiosurgery that were presented in the first article of this series. Finally, comments are made regarding the role of neural progenitor or stem cells in the repair of radiation-induced brain injury after radiosurgery. The importance of both the role of the extracellular matrix and properly directed axonal regrowth leading to appropriate target reinnervation is highlighted.

AB - IN THE FIRST part of this series, we reviewed the histological, radiographic, and molecular data gathered regarding the brain parenchymal response to radiosurgery and suggested future studies that could enhance our understanding of the topic. With this article, we begin by addressing methods of potentiating the effect of radiosurgery on target lesions of the central nervous system. Much of the work on potentiating the effects of cranial radiation has been performed in the field of whole-brain radiotherapy. Data from Phase III trials evaluating the efficacy of various agents as radiosensitizers or radioenhancers in whole-brain radiotherapy are reviewed, and trials for investigating certain agents as enhancers of radiosurgery are suggested. The roles of gene therapy and nanotechnology in enhancing the therapeutic efficacy of radiosurgery are then addressed. Focus is then shifted to a discussion of strategies of protecting healthy tissue from the potentially deleterious aspects of the brain's response to radiosurgery that were presented in the first article of this series. Finally, comments are made regarding the role of neural progenitor or stem cells in the repair of radiation-induced brain injury after radiosurgery. The importance of both the role of the extracellular matrix and properly directed axonal regrowth leading to appropriate target reinnervation is highlighted.

KW - Radiation enhancement

KW - Radiation injury

KW - Radiation potentiation

KW - Radiation protection

KW - Radiation repair

KW - Radiosensitizer

KW - Radiosurgery

UR - http://www.scopus.com/inward/record.url?scp=34247631116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247631116&partnerID=8YFLogxK

U2 - 10.1227/01.NEU.0000255454.28225.5C

DO - 10.1227/01.NEU.0000255454.28225.5C

M3 - Article

C2 - 17460515

AN - SCOPUS:34247631116

VL - 60

SP - 799

EP - 813

JO - Neurosurgery

JF - Neurosurgery

SN - 0148-396X

IS - 5

ER -