Stereotactic irradiation: Potential new treatment method for brain metastases resulting from ovarian cancer

Benjamin W. Corn, Minesh P. Mehta, John M. Buatti, Aaron H. Wolfson, Kathryn M. Greven, Robert Y. Kim, Charles J. Dunton, Jay S. Loeffler

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Stereotactic irradiation (radiosurgery) is a method of precisely focusing well-defined beams of radiation at small intracranial targets. The technique has been applied to the treatment of brain lesions that are benign (e.g., arteriovenous malformations, meningiomas, pituitary adenomas) and malignant (e.g., gliomas, metastases). This paper introduces preliminary data suggesting the possible value of radiosurgery in the management of ovarian cancer metastatic to the brain. Among 32 women with ovarian cancer metastatic to the brain treated with whole brain irradiation, nine (29%) experienced a complete radiographic response, compared with two of the five patients (40%) treated with radiosurgery. The 2-year survival rate was 60% among those treated with radiosurgery and 15% among those who received whole brain irradiation without radiosurgical boost. Stereotactic irradiation may be of clinical benefit to select patients with brain metastases resulting from ovarian cancer. A prospective randomized trial has been implemented by the Radiation Therapy Oncology Group (RTOG 95-08) to determine whether such observations are reproducible on a national scale.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume22
Issue number2
DOIs
StatePublished - Apr 1 1999

Keywords

  • Brain metastases
  • Ovarian cancer
  • Radiosurgery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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