Abstract
Two conformationally constrained tropane derivatives were prepared as rigid nicotinic acetylcholine receptor ligands. A palladium catalyzed intramolecular α-arylation reaction was employed to generate the tricyclic compounds in good yields from N-(bromo-chloropyridylmethyl)-8-azabicyclo[3.2.1]octan-3-ones.
Original language | English (US) |
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Pages (from-to) | 569-574 |
Number of pages | 6 |
Journal | Journal of Heterocyclic Chemistry |
Volume | 41 |
Issue number | 4 |
DOIs | |
State | Published - Jan 1 2004 |
ASJC Scopus subject areas
- Organic Chemistry