Stereoisomers of luteinizing hormone-releasing hormone

Yoshihiro Hirotsu, David H. Coy, Esther J. Coy, Andrew V Schally

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Six decapeptide analogs of the luteinizing hormone-releasing hormone (LH-RH) were prepared with the D-isomers of pyroglutamic acid, histidine, tryptophan, tyrosine, leucine, and arginine successively replacing the corresponding L-amino acids of the hormone. [D-pGlu1]-LH-RH and [D-His2]-LH-RH had appreciable LH-releasing activities, 8% and 9%, respectively. The remaining analogs were less potent, having the following activities: [D-Trp3]-LH-RH, 0.1%; [D-Tyr5]-LH-RH, 0.1%; [D-Leu7]-LH-RH, 1.0%; [D-Arg8]-LH-RH, 0.3%.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume59
Issue number1
DOIs
StatePublished - Jul 10 1974
Externally publishedYes

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Stereoisomerism
Gonadotropin-Releasing Hormone
tryptophan-leucine
Pyrrolidonecarboxylic Acid
Histidine
Leucine
Tryptophan
Isomers
Tyrosine
Arginine
Hormones
Amino Acids

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Stereoisomers of luteinizing hormone-releasing hormone. / Hirotsu, Yoshihiro; Coy, David H.; Coy, Esther J.; Schally, Andrew V.

In: Biochemical and Biophysical Research Communications, Vol. 59, No. 1, 10.07.1974, p. 277-282.

Research output: Contribution to journalArticle

Hirotsu, Yoshihiro ; Coy, David H. ; Coy, Esther J. ; Schally, Andrew V. / Stereoisomers of luteinizing hormone-releasing hormone. In: Biochemical and Biophysical Research Communications. 1974 ; Vol. 59, No. 1. pp. 277-282.
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