Abstract
Six decapeptide analogs of the luteinizing hormone-releasing hormone (LH-RH) were prepared with the D-isomers of pyroglutamic acid, histidine, tryptophan, tyrosine, leucine, and arginine successively replacing the corresponding L-amino acids of the hormone. [D-pGlu1]-LH-RH and [D-His2]-LH-RH had appreciable LH-releasing activities, 8% and 9%, respectively. The remaining analogs were less potent, having the following activities: [D-Trp3]-LH-RH, 0.1%; [D-Tyr5]-LH-RH, 0.1%; [D-Leu7]-LH-RH, 1.0%; [D-Arg8]-LH-RH, 0.3%.
| Original language | English |
|---|---|
| Pages (from-to) | 277-282 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 59 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 10 1974 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Stereoisomers of luteinizing hormone-releasing hormone. / Hirotsu, Yoshihiro; Coy, David H.; Coy, Esther J.; Schally, Andrew V.
In: Biochemical and Biophysical Research Communications, Vol. 59, No. 1, 10.07.1974, p. 277-282.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stereoisomers of luteinizing hormone-releasing hormone
AU - Hirotsu, Yoshihiro
AU - Coy, David H.
AU - Coy, Esther J.
AU - Schally, Andrew V
PY - 1974/7/10
Y1 - 1974/7/10
N2 - Six decapeptide analogs of the luteinizing hormone-releasing hormone (LH-RH) were prepared with the D-isomers of pyroglutamic acid, histidine, tryptophan, tyrosine, leucine, and arginine successively replacing the corresponding L-amino acids of the hormone. [D-pGlu1]-LH-RH and [D-His2]-LH-RH had appreciable LH-releasing activities, 8% and 9%, respectively. The remaining analogs were less potent, having the following activities: [D-Trp3]-LH-RH, 0.1%; [D-Tyr5]-LH-RH, 0.1%; [D-Leu7]-LH-RH, 1.0%; [D-Arg8]-LH-RH, 0.3%.
AB - Six decapeptide analogs of the luteinizing hormone-releasing hormone (LH-RH) were prepared with the D-isomers of pyroglutamic acid, histidine, tryptophan, tyrosine, leucine, and arginine successively replacing the corresponding L-amino acids of the hormone. [D-pGlu1]-LH-RH and [D-His2]-LH-RH had appreciable LH-releasing activities, 8% and 9%, respectively. The remaining analogs were less potent, having the following activities: [D-Trp3]-LH-RH, 0.1%; [D-Tyr5]-LH-RH, 0.1%; [D-Leu7]-LH-RH, 1.0%; [D-Arg8]-LH-RH, 0.3%.
UR - http://www.scopus.com/inward/record.url?scp=0016195559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016195559&partnerID=8YFLogxK
U2 - 10.1016/S0006-291X(74)80203-2
DO - 10.1016/S0006-291X(74)80203-2
M3 - Article
C2 - 4601814
AN - SCOPUS:0016195559
VL - 59
SP - 277
EP - 282
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -