Six decapeptide analogs of the luteinizing hormone-releasing hormone (LH-RH) were prepared with the D-isomers of pyroglutamic acid, histidine, tryptophan, tyrosine, leucine, and arginine successively replacing the corresponding L-amino acids of the hormone. [D-pGlu1]-LH-RH and [D-His2]-LH-RH had appreciable LH-releasing activities, 8% and 9%, respectively. The remaining analogs were less potent, having the following activities: [D-Trp3]-LH-RH, 0.1%; [D-Tyr5]-LH-RH, 0.1%; [D-Leu7]-LH-RH, 1.0%; [D-Arg8]-LH-RH, 0.3%.
|Original language||English (US)|
|Number of pages||6|
|Journal||Biochemical and biophysical research communications|
|State||Published - Jul 10 1974|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology