Stem cells for central nervous system repair and rehabilitation.

Gaby J. Ritfeld, Raymund A C Roos, Martin Oudega

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The central nervous system (CNS) has limited capacity for self-repair. Current treatments are often incapable of reversing the debilitating effects of CNS diseases that result in permanent and/or progressive physical and cognitive impairments. One promising repair strategy is transplantation of stem cells, which can potentially replace lost neurons and/or glia or promote repair through secretion of trophic factors. Various types of stem cells exist, each with their own advantages and disadvantages. Although no consensus exists regarding the optimal cell type to use, moderate functional improvements have been shown in animal models of CNS diseases using different types of stem cells. However, the precise mechanism of action behind their beneficial effects remains unknown. In addition, many barriers to clinical use still need to be resolved before transplantation of stem cells can be used as effective biologics. These barriers include--depending on the stem cell type--possible tumor formation, difficulty with harvest, limited in vivo differentiation and integration, and ethical issues regarding use.

Original languageEnglish (US)
JournalPM and R
Volume3
Issue number6 Suppl 1
StatePublished - Jun 2011
Externally publishedYes

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Central Nervous System Diseases
Stem Cell Transplantation
Stem Cells
Rehabilitation
Central Nervous System
Neoplastic Stem Cells
Biological Products
Ethics
Neuroglia
Consensus
Animal Models
Neurons
Therapeutics
Cognitive Dysfunction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Stem cells for central nervous system repair and rehabilitation. / Ritfeld, Gaby J.; Roos, Raymund A C; Oudega, Martin.

In: PM and R, Vol. 3, No. 6 Suppl 1, 06.2011.

Research output: Contribution to journalArticle

Ritfeld, GJ, Roos, RAC & Oudega, M 2011, 'Stem cells for central nervous system repair and rehabilitation.', PM and R, vol. 3, no. 6 Suppl 1.
Ritfeld, Gaby J. ; Roos, Raymund A C ; Oudega, Martin. / Stem cells for central nervous system repair and rehabilitation. In: PM and R. 2011 ; Vol. 3, No. 6 Suppl 1.
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