Abstract
In this chapter, we provide an overview of the potential advantages and disadvantages of different stem and progenitor cell populations identified to date in amniotic fluid, along with their properties and potential clinical applications. In the last ten years, placenta, fetal membranes (i.e., amnion and chorion), and amniotic fluid have been investigated as potentially uncontroversial sources of stem cells. Such tissues are typically discarded after delivery or are accessible during pregnancy through amniocentesis and chorionic villus sampling. Cell populations having multilineage differentiation potential and immunomodulatory properties have been isolated from the human placenta and fetal membranes, including human amniotic epithelial cells (hAECs), human amniotic mesenchymal stromal cells (hAMSCs), human chorionic mesenchymal stromal cells (hCMSCs), and human chorionic trophoblastic cells (hCTCs). From amniotic fluid (AF), two stem cell populations have been isolated: amniotic fluid mesenchymal stem cells (AFMSCs) and amniotic fluid stem (AFS) cells. It is possible that these cells may, given the easier accessibility of AF in comparison with other extra-embryonic tissues, hold much promise in regenerative medicine.
| Original language | English (US) |
|---|---|
| Title of host publication | Essentials of Stem Cell Biology: Third Edition |
| Publisher | Elsevier Inc. |
| Pages | 141-156 |
| Number of pages | 16 |
| ISBN (Print) | 9780124104273, 9780124095038 |
| DOIs | |
| State | Published - Nov 4 2013 |
| Externally published | Yes |
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Keywords
- Amniotic fluid
- Cell surface antigens
- Fetal origin
- Hematopoietic progenitor cells
- Mesenchymal stem cells
- Multilineage potential
- Transcriptome
ASJC Scopus subject areas
- Medicine(all)
Cite this
Stem Cells Derived from Amniotic Fluid. / Cananzi, Mara; Atala, Anthony; de Coppi, Paolo.
Essentials of Stem Cell Biology: Third Edition. Elsevier Inc., 2013. p. 141-156.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Stem Cells Derived from Amniotic Fluid
AU - Cananzi, Mara
AU - Atala, Anthony
AU - de Coppi, Paolo
PY - 2013/11/4
Y1 - 2013/11/4
N2 - In this chapter, we provide an overview of the potential advantages and disadvantages of different stem and progenitor cell populations identified to date in amniotic fluid, along with their properties and potential clinical applications. In the last ten years, placenta, fetal membranes (i.e., amnion and chorion), and amniotic fluid have been investigated as potentially uncontroversial sources of stem cells. Such tissues are typically discarded after delivery or are accessible during pregnancy through amniocentesis and chorionic villus sampling. Cell populations having multilineage differentiation potential and immunomodulatory properties have been isolated from the human placenta and fetal membranes, including human amniotic epithelial cells (hAECs), human amniotic mesenchymal stromal cells (hAMSCs), human chorionic mesenchymal stromal cells (hCMSCs), and human chorionic trophoblastic cells (hCTCs). From amniotic fluid (AF), two stem cell populations have been isolated: amniotic fluid mesenchymal stem cells (AFMSCs) and amniotic fluid stem (AFS) cells. It is possible that these cells may, given the easier accessibility of AF in comparison with other extra-embryonic tissues, hold much promise in regenerative medicine.
AB - In this chapter, we provide an overview of the potential advantages and disadvantages of different stem and progenitor cell populations identified to date in amniotic fluid, along with their properties and potential clinical applications. In the last ten years, placenta, fetal membranes (i.e., amnion and chorion), and amniotic fluid have been investigated as potentially uncontroversial sources of stem cells. Such tissues are typically discarded after delivery or are accessible during pregnancy through amniocentesis and chorionic villus sampling. Cell populations having multilineage differentiation potential and immunomodulatory properties have been isolated from the human placenta and fetal membranes, including human amniotic epithelial cells (hAECs), human amniotic mesenchymal stromal cells (hAMSCs), human chorionic mesenchymal stromal cells (hCMSCs), and human chorionic trophoblastic cells (hCTCs). From amniotic fluid (AF), two stem cell populations have been isolated: amniotic fluid mesenchymal stem cells (AFMSCs) and amniotic fluid stem (AFS) cells. It is possible that these cells may, given the easier accessibility of AF in comparison with other extra-embryonic tissues, hold much promise in regenerative medicine.
KW - Amniotic fluid
KW - Cell surface antigens
KW - Fetal origin
KW - Hematopoietic progenitor cells
KW - Mesenchymal stem cells
KW - Multilineage potential
KW - Transcriptome
UR - http://www.scopus.com/inward/record.url?scp=84942786689&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942786689&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-409503-8.00011-1
DO - 10.1016/B978-0-12-409503-8.00011-1
M3 - Chapter
AN - SCOPUS:84942786689
SN - 9780124104273
SN - 9780124095038
SP - 141
EP - 156
BT - Essentials of Stem Cell Biology: Third Edition
PB - Elsevier Inc.
ER -