Stem cells and myocardial repair

Victoria Florea, Monisha N. Banerjee, Luiza Bagno, Angela C. Rieger, Wayne Balkan, Joshua M. Hare

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The rising prevalence of cardiovascular disease and the limited treatment options necessitate new therapeutic approaches to stimulate cardiac repair. Stem cell administration has emerged as a novel treatment for cardiovascular disease and over the last two decades has been successfully translated from in vitro and preclinical studies to clinical trials. A variety of cell types have been administered in clinical trials to treat heart disease, with some demonstrating promising results to repair the damaged heart. However, their efficacy remains controversial and defining the ideal cell type, cell dose, route and timing of delivery and ideal patient population, remains a challenge. Here, we discuss lessons learned from previous clinical trials and propose future directions of cell-based therapy for cardiac disease.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Tissue Engineering and Regenerative Medicine
PublisherElsevier
Pages91-113
Number of pages23
Volume1-3
ISBN (Electronic)9780128136997
ISBN (Print)9780128137000
DOIs
StatePublished - Jan 1 2019

Keywords

  • Cardiac regeneration
  • Cardiac stem cells
  • Endothelial progenitor cell
  • Heart failure
  • Ischemic cardiomyopathy
  • Mesenchymal stem cells
  • Nonischemic cardiomyopathy
  • Stem cell therapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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