TY - JOUR
T1 - Stem cell therapy in autism
T2 - Recent insights
AU - Siniscalco, Dario
AU - Kannan, Suresh
AU - Semprún-Hernández, Neomar
AU - Eshraghi, Adrien A.
AU - Brigida, Anna Lisa
AU - Antonucci, Nicola
N1 - Publisher Copyright:
© 2018 Siniscalco et al.
PY - 2018
Y1 - 2018
N2 - Autism spectrum disorders (ASDs) are characterized by core domains: persistent deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities. ASDs comprise heterogeneous and complex neurodevelopmental pathologies with well-defined inflammatory conditions and immune system dysfunction. Due to neurobiologic changes underlying ASD development, cell-based therapies have been proposed and applied to ASDs. Indeed, stem cells show specific immunologic properties, which make them promising candidates in ASD treatment. This comprehensive up-to-date review focuses on ASD cellular/ molecular abnormalities, potentially useful stem cell types, animal models, and current clinical trials on the use of stem cells in treating autism. Limitations are also discussed.
AB - Autism spectrum disorders (ASDs) are characterized by core domains: persistent deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities. ASDs comprise heterogeneous and complex neurodevelopmental pathologies with well-defined inflammatory conditions and immune system dysfunction. Due to neurobiologic changes underlying ASD development, cell-based therapies have been proposed and applied to ASDs. Indeed, stem cells show specific immunologic properties, which make them promising candidates in ASD treatment. This comprehensive up-to-date review focuses on ASD cellular/ molecular abnormalities, potentially useful stem cell types, animal models, and current clinical trials on the use of stem cells in treating autism. Limitations are also discussed.
KW - Autism spectrum disorder
KW - Cell therapy
KW - Immune dysfunction
KW - Stem cell
UR - http://www.scopus.com/inward/record.url?scp=85064884213&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064884213&partnerID=8YFLogxK
U2 - 10.2147/SCCAA.S155410
DO - 10.2147/SCCAA.S155410
M3 - Review article
AN - SCOPUS:85064884213
VL - 11
SP - 55
EP - 67
JO - Stem Cells and Cloning: Advances and Applications
JF - Stem Cells and Cloning: Advances and Applications
SN - 1178-6957
ER -