Stem cell therapy in autism: Recent insights

Dario Siniscalco, Suresh Kannan, Neomar Semprún-Hernández, Adrien A. Eshraghi, Anna Lisa Brigida, Nicola Antonucci

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Autism spectrum disorders (ASDs) are characterized by core domains: persistent deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities. ASDs comprise heterogeneous and complex neurodevelopmental pathologies with well-defined inflammatory conditions and immune system dysfunction. Due to neurobiologic changes underlying ASD development, cell-based therapies have been proposed and applied to ASDs. Indeed, stem cells show specific immunologic properties, which make them promising candidates in ASD treatment. This comprehensive up-to-date review focuses on ASD cellular/ molecular abnormalities, potentially useful stem cell types, animal models, and current clinical trials on the use of stem cells in treating autism. Limitations are also discussed.

Original languageEnglish (US)
Pages (from-to)55-67
Number of pages13
JournalStem Cells and Cloning: Advances and Applications
Volume11
DOIs
StatePublished - Jan 1 2018

Keywords

  • Autism spectrum disorder
  • Cell therapy
  • Immune dysfunction
  • Stem cell

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Cell Biology

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    Siniscalco, D., Kannan, S., Semprún-Hernández, N., Eshraghi, A. A., Brigida, A. L., & Antonucci, N. (2018). Stem cell therapy in autism: Recent insights. Stem Cells and Cloning: Advances and Applications, 11, 55-67. https://doi.org/10.2147/SCCAA.S155410