Stem cell therapy in Alzheimer’s disease

Milena Pinto, Christian Camargo, Michelle Marrero, Bernard Baumel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter presents the scientific rationale and evidence for using stem cells to treat Alzheimer’s disease. There is sufficient evidence that these cells are effective in reducing inflammation as well as in promoting regeneration. The authors outline the preclinical work that justifies stem cell therapeutic trials in humans. The various stem cell types used in preclinical studies are discussed. Their mechanism of action in in-vivo animal studies and the results of these studies are discussed. Then, the human experience in using transplanted stem cells is reviewed. We examine what cell properties are necessary to treat Alzheimer’s disease. We describe what cell types have the most compelling evidence today for their safe use in clinical trials. Some of these lessons have been learned from the experiences of treating other neurological diseases with stem cells.

Original languageEnglish (US)
Title of host publicationRecent Advances in iPSCs for Therapy, Volume 3
Subtitle of host publicationA Volume in Advances in Stem Cell Biology
PublisherElsevier
Pages97-132
Number of pages36
ISBN (Electronic)9780128222294
DOIs
StatePublished - Jan 1 2021
Externally publishedYes

Keywords

  • Alzheimer’s disease
  • Differentiation
  • MSC
  • Nervous system
  • SGZ
  • Stem cell

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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