Stem cell therapies for renal diseases

Angela C. Rieger; Luiza Bagno; Victoria Florea; Ivonne H. Schulman

doi:10.1016/B978-0-12-801238-3.65447-8

Stem cell therapies for renal diseases

Angela C. Rieger, Luiza Bagno, Victoria Florea, Ivonne H. Schulman

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Kidney disease is a public health priority, due to its morbidity and mortality with limited therapeutic options. Stem cell therapies are undergoing investigation to improve the regenerative capacity of the kidney. The mechanisms underlying the reparative effects of stem cells include antiinflammatory, immunomodulatory, antiapoptotic, and pro-angiogenic properties. Stem cell clinical trials have shown efficacy in improving kidney transplantation success, whereas variable responses have been observed in acute and chronic kidney diseases, depending on various variables including disease background, cell type, route of administration, and patient population. In this article, we review the state of the stem cell therapy field in kidney disease.

Original language	English (US)
Title of host publication	Encyclopedia of Tissue Engineering and Regenerative Medicine
Publisher	Elsevier
Pages	127-136
Number of pages	10
Volume	1-3
ISBN (Electronic)	9780128136997
ISBN (Print)	9780128137000
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.65447-8
State	Published - Jan 1 2019
Externally published	Yes

Keywords

Acute kidney injury
Cell-based therapy
Chronic kidney disease
Endothelial progenitor cells
Exosomes
Kidney transplantation
Mesenchymal stem cells
Paracrine signaling
Regenerative medicine

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/B978-0-12-801238-3.65447-8

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abstract = "Kidney disease is a public health priority, due to its morbidity and mortality with limited therapeutic options. Stem cell therapies are undergoing investigation to improve the regenerative capacity of the kidney. The mechanisms underlying the reparative effects of stem cells include antiinflammatory, immunomodulatory, antiapoptotic, and pro-angiogenic properties. Stem cell clinical trials have shown efficacy in improving kidney transplantation success, whereas variable responses have been observed in acute and chronic kidney diseases, depending on various variables including disease background, cell type, route of administration, and patient population. In this article, we review the state of the stem cell therapy field in kidney disease.",

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AU - Bagno, Luiza

AU - Florea, Victoria

AU - Schulman, Ivonne H.

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KW - Endothelial progenitor cells

KW - Exosomes

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KW - Mesenchymal stem cells

KW - Paracrine signaling

KW - Regenerative medicine

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