Stem cell therapies for renal diseases

Angela C. Rieger, Luiza Bagno, Victoria Florea, Ivonne H. Schulman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Kidney disease is a public health priority, due to its morbidity and mortality with limited therapeutic options. Stem cell therapies are undergoing investigation to improve the regenerative capacity of the kidney. The mechanisms underlying the reparative effects of stem cells include antiinflammatory, immunomodulatory, antiapoptotic, and pro-angiogenic properties. Stem cell clinical trials have shown efficacy in improving kidney transplantation success, whereas variable responses have been observed in acute and chronic kidney diseases, depending on various variables including disease background, cell type, route of administration, and patient population. In this article, we review the state of the stem cell therapy field in kidney disease.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Tissue Engineering and Regenerative Medicine
PublisherElsevier
Pages127-136
Number of pages10
Volume1-3
ISBN (Electronic)9780128136997
ISBN (Print)9780128137000
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • Acute kidney injury
  • Cell-based therapy
  • Chronic kidney disease
  • Endothelial progenitor cells
  • Exosomes
  • Kidney transplantation
  • Mesenchymal stem cells
  • Paracrine signaling
  • Regenerative medicine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Rieger, A. C., Bagno, L., Florea, V., & Schulman, I. H. (2019). Stem cell therapies for renal diseases. In Encyclopedia of Tissue Engineering and Regenerative Medicine (Vol. 1-3, pp. 127-136). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.65447-8