Stem cell based therapy for lung disease preclinical evidence for the role of stem/stromal cells clinical application of stem/stromal cells in lung fibrosis

Carissa L. Patete, R. L. Toonkel, Marilyn Glassberg

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Preclinical studies suggest that mesenchymal stem cells (MSCs) may represent a potential therapeutic option for the treatment of chronic lung diseases including Idiopathic Pulmonary Fibrosis (IPF). IPF is an inexorably progressive lung disease of unknown origin. Despite the recent availability of two approved treatment options, median survival remains poor at 3–5 years. While there remains a pressing need for further exploration of interval endpoints and biomarkers, promising results of Phase 1 studies of MSCs have reduced safety concerns and encouraged further interest in the potential applicability of cell-based therapeutic approaches for chronic lung diseases like IPF. This chapter will summarize the current state of knowledge regarding the use of stem cells for the treatment of IPF, present important safety and efficacy issues highlighting current and future challenges, and address the need for large, multicenter clinical trials coupled with realistic end-points, including biomarkers, to assess treatment efficacy.

Original languageEnglish (US)
Title of host publicationStem Cell-Based Therapy for Lung Disease
PublisherSpringer International Publishing
Pages119-130
Number of pages12
ISBN (Electronic)9783030294038
ISBN (Print)9783030294021
DOIs
StatePublished - Jan 1 2019

Keywords

  • Efficacy
  • Idiopathic pulmonary fibrosis
  • Mesenchymal stem cells
  • Safety
  • Treatment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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