Stem and progenitor cell therapies: Recent progress for spinal cord injury repair

J. Louro, D. D. Pearse

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Mechanical trauma to the spinal cord is often accompanied by irreversible tissue damage, limited endogenous repair and permanent loss of motor, sensory and autonomic function. The implantation of exogenous cells or the stimulation of endogenous cells, to repopulate and replace or to provide a conducive environment for repair, offers a promising therapeutic direction for overcoming the multitude of obstacles facing successful recovery from spinal cord injury. Although relatively new to the scene of cell based therapies for reparative medicine, stem cells and their progenitors have been labeled as the 'cell of the future' for revolutionizing the treatment of CNS injury and neurodegenerative disorders. The following review examines the different types of stem cells and their progenitors, their utility in experimental models of spinal cord injury and explores the outstanding issues that still need to be addressed before they move towards clinical implementation.

Original languageEnglish (US)
Pages (from-to)5-16
Number of pages12
JournalNeurological Research
Volume30
Issue number1
DOIs
StatePublished - Feb 1 2008

Keywords

  • Cell implantation
  • Repair
  • Spinal cord injury
  • Stem and progenitor cells

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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