Steady-state pattern electroretinogram in insulin-dependent diabetics with no or minimal retinopathy

Benedetto Falsini, Vittorio Porciatti, Giuseppe Scalia, Salvatore Caputo, Angelo Minnella, Mauro A.S. Di Leo, Giovanni Ghirlanda

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Steady-state pattern electroretinogram (PERG) in response to sinusoidal gratings (1.7 c/deg spatial frequency; 9 × 9 deg field size) temporally modulated (sinusoidally) at 8 Hz were recorded in 40 insulin-dependent diabetics and 28 age-matched normal subjects. Visual acuity was ≥ 20/20 in all 40 patients; 31 (62 eyes) showed no sign of retinopathy and nine (18 eyes) showed a few microaneurysms on fluorescein angiography. Insulin-dependent diabetics showed a significant reduction in the PERG mean amplitude as compared with age-matched control subjects (one-way analysis of variance: p < 0.0001). Significant differences were observed between normals and diabetics without retinopathy (Scheffé test: p < 0.0001), normals and diabetics with early retinopathy (Scheffé test: p < 0.0001), no retinopathy and early retinopathy patients (Scheffé test: p < 0.05). In diabetics without retinopathy multi-factorial analysis of variance revealed a significant effect of age of onset of the disease (p < 0.01) and an interaction effect between age of onset and duration (p < 0.001) on PERG amplitude. These results suggest a possible use of the steady-state PERG to detect early macular dysfunction in insulin-dependent diabetics.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalDocumenta Ophthalmologica
Issue number2
StatePublished - Oct 1989
Externally publishedYes


  • insulin-dependent diabetes
  • pattern electroretinogram
  • sinusoidal gratings
  • steady-state analysis

ASJC Scopus subject areas

  • Ophthalmology


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