Steady-state pattern electroretinogram in insulin-dependent diabetics with no or minimal retinopathy

Benedetto Falsini, Vittorio Porciatti, Giuseppe Scalia, Salvatore Caputo, Angelo Minnella, Mauro A S Di Leo, Giovanni Ghirlanda

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Steady-state pattern electroretinogram (PERG) in response to sinusoidal gratings (1.7 c/deg spatial frequency; 9 × 9 deg field size) temporally modulated (sinusoidally) at 8 Hz were recorded in 40 insulin-dependent diabetics and 28 age-matched normal subjects. Visual acuity was ≥ 20/20 in all 40 patients; 31 (62 eyes) showed no sign of retinopathy and nine (18 eyes) showed a few microaneurysms on fluorescein angiography. Insulin-dependent diabetics showed a significant reduction in the PERG mean amplitude as compared with age-matched control subjects (one-way analysis of variance: p < 0.0001). Significant differences were observed between normals and diabetics without retinopathy (Scheffé test: p < 0.0001), normals and diabetics with early retinopathy (Scheffé test: p < 0.0001), no retinopathy and early retinopathy patients (Scheffé test: p < 0.05). In diabetics without retinopathy multi-factorial analysis of variance revealed a significant effect of age of onset of the disease (p < 0.01) and an interaction effect between age of onset and duration (p < 0.001) on PERG amplitude. These results suggest a possible use of the steady-state PERG to detect early macular dysfunction in insulin-dependent diabetics.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalDocumenta Ophthalmologica
Volume73
Issue number2
DOIs
StatePublished - Oct 1 1989
Externally publishedYes

Fingerprint

Diabetic Retinopathy
Insulin
Age of Onset
Analysis of Variance
Fluorescein Angiography
Visual Acuity
Microaneurysm

Keywords

  • insulin-dependent diabetes
  • pattern electroretinogram
  • sinusoidal gratings
  • steady-state analysis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Steady-state pattern electroretinogram in insulin-dependent diabetics with no or minimal retinopathy. / Falsini, Benedetto; Porciatti, Vittorio; Scalia, Giuseppe; Caputo, Salvatore; Minnella, Angelo; Di Leo, Mauro A S; Ghirlanda, Giovanni.

In: Documenta Ophthalmologica, Vol. 73, No. 2, 01.10.1989, p. 193-200.

Research output: Contribution to journalArticle

Falsini, Benedetto ; Porciatti, Vittorio ; Scalia, Giuseppe ; Caputo, Salvatore ; Minnella, Angelo ; Di Leo, Mauro A S ; Ghirlanda, Giovanni. / Steady-state pattern electroretinogram in insulin-dependent diabetics with no or minimal retinopathy. In: Documenta Ophthalmologica. 1989 ; Vol. 73, No. 2. pp. 193-200.
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