TY - JOUR
T1 - Statistical evaluation of the persistence of acquired hypersensitivity by standardized patch tests
AU - Ayala, Fabio
AU - Balato, Nicola
AU - Lembo, Giuseppe
AU - Patruno, Cataldo
AU - Fabbrocini, Gabriella
AU - Nofroni, Italo
AU - Magliocchetti, Natalia
AU - Schena, Donatella
AU - Rafanelli, Arturo
AU - Seidenari, Stefania
AU - Motolese, Alberico
AU - Angelini, Giovanni
AU - Tosti, Antonella
AU - Saccabusi, Stanislao
AU - Pigatto, Paolo
AU - Lisi, Paolo
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1996
Y1 - 1996
N2 - Numerous studies have focused attention on the influence of various biological and environmental factors on contact hypersensitivity. In order to evaluate the persistence and/or modification of allergic contact sensitivity to a number of common contact sensitizers, the same standardized patch tests were repeated on 174 subjects with contact sensitivity after a time lapse of 5 years (1987-1992). In 18.4% of the cases, 1 or more sensitivities were lost; 28.7% of the patients had a higher number of positive patch tests after 5 years, while the remaining 52.9% of the patients showed no change in the number of positive patch tests. In 88%, the positive allergens were unchanged, whereas in the remaining 12% of the subjects, they showed 1 or more variations. The association between the remaining most often positive was calculated for both the 1st and the 2nd patch test results. Moreover, to evaluate the frequency of an allergen's positivity, we studied the disappearance of old sensitivities and the appearance of new sensitivities by the McNemar test. Cobalt chloride was the only allergen with a significant frequency of new positivities over the period of observation (p < 0.01). Logistic regression analysis was performed to evaluate the possible influence of positive tests to other allergens, and of some clinical findings associated with contact dermatitis, on the sensitivity to cobalt chloride in 1987 and in 1992.
AB - Numerous studies have focused attention on the influence of various biological and environmental factors on contact hypersensitivity. In order to evaluate the persistence and/or modification of allergic contact sensitivity to a number of common contact sensitizers, the same standardized patch tests were repeated on 174 subjects with contact sensitivity after a time lapse of 5 years (1987-1992). In 18.4% of the cases, 1 or more sensitivities were lost; 28.7% of the patients had a higher number of positive patch tests after 5 years, while the remaining 52.9% of the patients showed no change in the number of positive patch tests. In 88%, the positive allergens were unchanged, whereas in the remaining 12% of the subjects, they showed 1 or more variations. The association between the remaining most often positive was calculated for both the 1st and the 2nd patch test results. Moreover, to evaluate the frequency of an allergen's positivity, we studied the disappearance of old sensitivities and the appearance of new sensitivities by the McNemar test. Cobalt chloride was the only allergen with a significant frequency of new positivities over the period of observation (p < 0.01). Logistic regression analysis was performed to evaluate the possible influence of positive tests to other allergens, and of some clinical findings associated with contact dermatitis, on the sensitivity to cobalt chloride in 1987 and in 1992.
KW - Cobalt
KW - Contact allergy
KW - Epidemiology
KW - Follow-up study
KW - Loss of sensitivities
KW - New sensitivities
KW - Patch test
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U2 - 10.1111/j.1600-0536.1996.tb02222.x
DO - 10.1111/j.1600-0536.1996.tb02222.x
M3 - Article
C2 - 8807230
AN - SCOPUS:8944245003
VL - 34
SP - 354
EP - 358
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 5
ER -