Statins as potential therapeutic agents for healing disorders

Olivera Stojadinovic, Elizabeth Lebrun, Irena Pastar, Robert Kirsner, Stephen C. Davis, Marjana Tomic-Canic

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Statins, HMG-CoA reductase inhibitors, are common cholesterol-lowering drugs. Recent studies suggest that statins may have potential as novel treatments for diverse conditions, ranging from sepsis and inflammatory diseases to chronic wounds and bone fractures. The diverse pleiotropic actions of statins are probably related to reduced isoprenylation of downstream targets of the mevalonate pathway and their binding to several nuclear hormone receptors. Statins exert their anti-inflammatory effect by inhibiting the release of C-reactive peptide, chemokines, cytokines and adhesion molecules, which may make them a powerful addition to the dermatologic anti-inflammatory medication arsenal. Along with reducing inflammation, statins have the potential to heal chronic wounds by decreasing farnesyl pyrophosphate, facilitating vascular relaxation, promoting neovascularization and reducing bacterial load. A review of the literature elucidates that route of administration, dose and type of statin appear to impact the outcome. A better understanding of their effects at the cellular and molecular level in skin is necessary for their future use.

Original languageEnglish (US)
Pages (from-to)689-698
Number of pages10
JournalExpert Review of Dermatology
Volume5
Issue number6
DOIs
StatePublished - Dec 1 2010

Keywords

  • angiogenesis
  • chronic wounds
  • diabetes
  • inflammation
  • skin
  • statins
  • wound healing

ASJC Scopus subject areas

  • Dermatology

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