Startle response in behaviorally inhibited adolescents with a lifetime occurrence of anxiety disorders

Bethany C. Reeb-Sutherland, Sarah M. Helfinstein, Kathryn A. Degnan, Koraly Perez-Edgar, Heather A. Henderson, Shmuel Lissek, Andrea Chronis-Tuscano, Christian Grillon, Daniel S. Pine, Nathan A. Fox

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Objective: Behaviorally inhibited children face increased risk for anxiety disorders, although factors that predict which children develop a disorder remain poorly specified. The current study examines whether the startle reflex response may be used to differentiate between behaviorally inhibited adolescents with and without a history of anxiety. Method: Participants were assessed for behavioral inhibition during toddlerhood and early childhood. They returned to the laboratory as adolescents and completed a fear-potentiated startle paradigm and a clinical diagnostic interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version). Magnitude of the startle reflex was examined at baseline and during cues associated with safety and threat. Results: Only adolescents who showed high levels of behavioral inhibition and had a lifetime occurrence of anxiety disorders showed increased startle reactivity in the presence of safety cues. Neither behavioral inhibition nor diagnosis was related to startle reactivity during threat cues. Conclusions: These results suggest that neurobiological measures, such as the startle reflex, may be a potential risk marker for the development of anxiety disorders among behaviorally inhibited adolescents. These methods may enhance our ability to identify vulnerable individuals before the development of anxious psychopathology. J. Am. Acad. Child Adolesc.

Original languageEnglish
Pages (from-to)610-617
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume48
Issue number6
DOIs
StatePublished - Jun 1 2009

Fingerprint

Startle Reflex
Anxiety Disorders
Cues
Safety
Aptitude
Psychopathology
Mood Disorders
Fear
Schizophrenia
Appointments and Schedules
Anxiety
Interviews
Inhibition (Psychology)

Keywords

  • Adolescence
  • Anxiety
  • Risk factors
  • Startle
  • Temperament

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

Cite this

Reeb-Sutherland, B. C., Helfinstein, S. M., Degnan, K. A., Perez-Edgar, K., Henderson, H. A., Lissek, S., ... Fox, N. A. (2009). Startle response in behaviorally inhibited adolescents with a lifetime occurrence of anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 48(6), 610-617. https://doi.org/10.1097/CHI.0b013e31819f70fb

Startle response in behaviorally inhibited adolescents with a lifetime occurrence of anxiety disorders. / Reeb-Sutherland, Bethany C.; Helfinstein, Sarah M.; Degnan, Kathryn A.; Perez-Edgar, Koraly; Henderson, Heather A.; Lissek, Shmuel; Chronis-Tuscano, Andrea; Grillon, Christian; Pine, Daniel S.; Fox, Nathan A.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 48, No. 6, 01.06.2009, p. 610-617.

Research output: Contribution to journalArticle

Reeb-Sutherland, BC, Helfinstein, SM, Degnan, KA, Perez-Edgar, K, Henderson, HA, Lissek, S, Chronis-Tuscano, A, Grillon, C, Pine, DS & Fox, NA 2009, 'Startle response in behaviorally inhibited adolescents with a lifetime occurrence of anxiety disorders', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 48, no. 6, pp. 610-617. https://doi.org/10.1097/CHI.0b013e31819f70fb
Reeb-Sutherland, Bethany C. ; Helfinstein, Sarah M. ; Degnan, Kathryn A. ; Perez-Edgar, Koraly ; Henderson, Heather A. ; Lissek, Shmuel ; Chronis-Tuscano, Andrea ; Grillon, Christian ; Pine, Daniel S. ; Fox, Nathan A. / Startle response in behaviorally inhibited adolescents with a lifetime occurrence of anxiety disorders. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2009 ; Vol. 48, No. 6. pp. 610-617.
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