Stanford V program for locally extensive and advanced Hodgkin lymphoma: The Memorial Sloan-Kettering Cancer Center experience

S. M. Edwards-Bennett, L. M. Jacks, C. H. Moskowitz, E. J. Wu, Z. Zhang, A. Noy, C. S. Portlock, D. J. Straus, A. D. Zelenetz, J. Yahalom

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Background: The Stanford group has reported excellent results with the Stanford V regimen for patients with bulky and/or advanced Hodgkin lymphoma (HL). However, Gobbi reported markedly inferior failure-free survival (FFS) comparing Stanford V to other regimens but included major deviations from the original program. We retrospectively examined whether treatment at our institution carefully following Stanford V guidelines would confirm the original Stanford outcome data. Patients and methods: From June 1995 to May 2002, 126 patients with either locally extensive or advanced HL were treated with the 12-week Stanford V chemotherapy program followed by 36-Gy involved-field radiotherapy to sites initially ≥5 cm and/or to macroscopic splenic disease. Overall, 26% had stage IV disease and 20% had international prognostic score (IPS) ≥4. Overall survival (OS), disease-specific survival, progression-free survival (PFS), FFS, and freedom from second relapse (FF2R) were determined. Results: The 5- and 7-year OS were 90% and 88%, respectively. The 5-year FFS was 78%. IPS ≥4 was a significant independent predictor of worse OS and PFS. The FF2R was 64% at 3 years. Conclusion: Stanford V with appropriate radiotherapy is a highly effective regimen for locally extensive and advanced HL.

Original languageEnglish (US)
Article numbermdp337
Pages (from-to)574-581
Number of pages8
JournalAnnals of Oncology
Volume21
Issue number3
DOIs
StatePublished - Sep 16 2009

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Keywords

  • Combined modality
  • Hodgkin lymphoma
  • Involved-field radiotherapy
  • Stanford V

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Edwards-Bennett, S. M., Jacks, L. M., Moskowitz, C. H., Wu, E. J., Zhang, Z., Noy, A., Portlock, C. S., Straus, D. J., Zelenetz, A. D., & Yahalom, J. (2009). Stanford V program for locally extensive and advanced Hodgkin lymphoma: The Memorial Sloan-Kettering Cancer Center experience. Annals of Oncology, 21(3), 574-581. [mdp337]. https://doi.org/10.1093/annonc/mdp337