Staging of neuroblastoma at imaging: Report of the radiology diagnostic oncology group

Marilyn J. Siegel, Hemant Ishwaran, Barry D. Fletcher, James S. Meyer, Fredric A. Hoffer, Diego Jaramillo, Ramiro J. Hernandez, Susan E. Roubal, Barry A. Siegel, Daryl J. Caudry, Barbara J. McNeil

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

PURPOSE: To compare the accuracies of computed tomography (CT), magnetic resonance (MR) imaging, and bone scintigraphy in staging disease in patients with neuroblastoma. MATERIALS AND METHODS: Ninety-six children with newly diagnosed neuroblastoma were enrolled in a multicenter prospective cohort study. CT, MR, and bone scintigraphy were used to evaluate tumor stage. Sensitivity and specificity values and receiver operating characteristic (ROC) curve analyses were used to compare the accuracy of CT, MR, and scintigraphy for tumor staging. RESULTS: Eighty-eight patients were eligible for staging analysis, and 45 patients who underwent surgery at initial diagnosis were eligible for analysis of local tumor extent. CT and MR had sensitivities of 43% and 83%, respectively (P < .01), and specificities of 97% and 88%, respectively (P > .05), for detection of stage 4 disease. Areas under the ROC curves for CT and MR were 0.81 and 0.85, respectively (P = .06); that for scintigraphy was 0.83. Addition of scintigraphy to both CT and MR increased the areas under the ROC curves to 0.90 and 0.88, respectively. Accuracy of CT and MR for staging disease confined to the chest or abdomen (stages 1, 2, and 3) was poor. CONCLUSION: MR alone and CT and MR combined with bone scintigraphy enable the accurate detection of stage 4 disease. Both CT and MR perform poorly for local tumor staging.

Original languageEnglish
Pages (from-to)168-175
Number of pages8
JournalRadiology
Volume223
Issue number1
StatePublished - Apr 9 2002
Externally publishedYes

Fingerprint

Neuroblastoma
Radiology
Magnetic Resonance Spectroscopy
Tomography
Radionuclide Imaging
ROC Curve
Neoplasm Staging
Bone and Bones
Abdomen
Neoplasms
Cohort Studies
Thorax
Magnetic Resonance Imaging
Prospective Studies
Sensitivity and Specificity

Keywords

  • Computed tomography (CT), comparative studies
  • Magnetic resonance (MR), comparative studies
  • Neoplasms, staging
  • Neuroblastoma
  • Radionuclides, comparative studies

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Siegel, M. J., Ishwaran, H., Fletcher, B. D., Meyer, J. S., Hoffer, F. A., Jaramillo, D., ... McNeil, B. J. (2002). Staging of neuroblastoma at imaging: Report of the radiology diagnostic oncology group. Radiology, 223(1), 168-175.

Staging of neuroblastoma at imaging : Report of the radiology diagnostic oncology group. / Siegel, Marilyn J.; Ishwaran, Hemant; Fletcher, Barry D.; Meyer, James S.; Hoffer, Fredric A.; Jaramillo, Diego; Hernandez, Ramiro J.; Roubal, Susan E.; Siegel, Barry A.; Caudry, Daryl J.; McNeil, Barbara J.

In: Radiology, Vol. 223, No. 1, 09.04.2002, p. 168-175.

Research output: Contribution to journalArticle

Siegel, MJ, Ishwaran, H, Fletcher, BD, Meyer, JS, Hoffer, FA, Jaramillo, D, Hernandez, RJ, Roubal, SE, Siegel, BA, Caudry, DJ & McNeil, BJ 2002, 'Staging of neuroblastoma at imaging: Report of the radiology diagnostic oncology group', Radiology, vol. 223, no. 1, pp. 168-175.
Siegel MJ, Ishwaran H, Fletcher BD, Meyer JS, Hoffer FA, Jaramillo D et al. Staging of neuroblastoma at imaging: Report of the radiology diagnostic oncology group. Radiology. 2002 Apr 9;223(1):168-175.
Siegel, Marilyn J. ; Ishwaran, Hemant ; Fletcher, Barry D. ; Meyer, James S. ; Hoffer, Fredric A. ; Jaramillo, Diego ; Hernandez, Ramiro J. ; Roubal, Susan E. ; Siegel, Barry A. ; Caudry, Daryl J. ; McNeil, Barbara J. / Staging of neuroblastoma at imaging : Report of the radiology diagnostic oncology group. In: Radiology. 2002 ; Vol. 223, No. 1. pp. 168-175.
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AU - Hernandez, Ramiro J.

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N2 - PURPOSE: To compare the accuracies of computed tomography (CT), magnetic resonance (MR) imaging, and bone scintigraphy in staging disease in patients with neuroblastoma. MATERIALS AND METHODS: Ninety-six children with newly diagnosed neuroblastoma were enrolled in a multicenter prospective cohort study. CT, MR, and bone scintigraphy were used to evaluate tumor stage. Sensitivity and specificity values and receiver operating characteristic (ROC) curve analyses were used to compare the accuracy of CT, MR, and scintigraphy for tumor staging. RESULTS: Eighty-eight patients were eligible for staging analysis, and 45 patients who underwent surgery at initial diagnosis were eligible for analysis of local tumor extent. CT and MR had sensitivities of 43% and 83%, respectively (P < .01), and specificities of 97% and 88%, respectively (P > .05), for detection of stage 4 disease. Areas under the ROC curves for CT and MR were 0.81 and 0.85, respectively (P = .06); that for scintigraphy was 0.83. Addition of scintigraphy to both CT and MR increased the areas under the ROC curves to 0.90 and 0.88, respectively. Accuracy of CT and MR for staging disease confined to the chest or abdomen (stages 1, 2, and 3) was poor. CONCLUSION: MR alone and CT and MR combined with bone scintigraphy enable the accurate detection of stage 4 disease. Both CT and MR perform poorly for local tumor staging.

AB - PURPOSE: To compare the accuracies of computed tomography (CT), magnetic resonance (MR) imaging, and bone scintigraphy in staging disease in patients with neuroblastoma. MATERIALS AND METHODS: Ninety-six children with newly diagnosed neuroblastoma were enrolled in a multicenter prospective cohort study. CT, MR, and bone scintigraphy were used to evaluate tumor stage. Sensitivity and specificity values and receiver operating characteristic (ROC) curve analyses were used to compare the accuracy of CT, MR, and scintigraphy for tumor staging. RESULTS: Eighty-eight patients were eligible for staging analysis, and 45 patients who underwent surgery at initial diagnosis were eligible for analysis of local tumor extent. CT and MR had sensitivities of 43% and 83%, respectively (P < .01), and specificities of 97% and 88%, respectively (P > .05), for detection of stage 4 disease. Areas under the ROC curves for CT and MR were 0.81 and 0.85, respectively (P = .06); that for scintigraphy was 0.83. Addition of scintigraphy to both CT and MR increased the areas under the ROC curves to 0.90 and 0.88, respectively. Accuracy of CT and MR for staging disease confined to the chest or abdomen (stages 1, 2, and 3) was poor. CONCLUSION: MR alone and CT and MR combined with bone scintigraphy enable the accurate detection of stage 4 disease. Both CT and MR perform poorly for local tumor staging.

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