Stable growth transformation of human T lymphocytes by Herpesvirus saimiri

Brigitte Biesinger, Ingrid Müller-Fleckenstein, Birgit Simmer, Gerlinde Lang, Sabine Wittmann, Erich Platzer, Ronald C. Desrosiers, Bernhard Fleckenstein

Research output: Contribution to journalArticle

269 Scopus citations

Abstract

Herpesvirus saimiri induces T-cell lymphomas in various species of New World monkeys and in rabbits, and it is able to immortalize monkey T lymphocytes in vitro. Sequences responsible for these effects have been localized to a region of the genome that varies significantly among the virus subgroups A, B, and C. We now report that infection of human blood lymphocytes and thymocytes with strains of subgroup C, in contrast to viruses of the other subgroups, yields continuously proliferating T-cell lines with the phenotype of mature CD4- or CD8-positive cells. Infection with strains of Herpesvirus saimiri subgroup C can thus be used to generate human T-cell lines for a variety of immunological and developmental studies.

Original languageEnglish (US)
Pages (from-to)3116-3119
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number7
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Keywords

  • CD4 and
  • Oncogenic herpesvirus
  • Or CD8 cell lines

ASJC Scopus subject areas

  • General

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